Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio)chemical analysis. Strong synergy arises …

Eukaryotic elongation factor 2 kinase (eEF2K), an atypical calmodulin-dependent protein
kinase, phosphorylates and inhibits eEF2, slowing down translation elongation. eEF2K …

Protein post‐translational modifications (PTMs) are critically important in regulating both
protein structure and function, often in a rapid and reversible manner. Due to its sensitivity and …

The mechanisms of oxidative N-dealkylation of amines by heme enzymes including peroxidases
and cytochromes P450 and by functional models for the active Compound I species …

Many genetic and environmental factors lead to interindividual variations in the metabolism
and transport of drugs, profoundly affecting efficacy and toxicity. Precision dosing, that is, …

High-valent transition-metal–oxo complexes are electrophilic oxidants implicated in a variety
of biological processes and chemical transformations.[1] Manganese (V)–oxo species are …

Anionic σ complexes, also referred to as “Jackson–Meisenheimer” or “Meisenheimer”
complexes, are key intermediates in the SNAr mechanism of aromatic nucleophilic substitution …

Model ferric heme nitrosyl complexes, [Fe(TPP)(NO)] + and [Fe(TPFPP)(NO)] + , where TPP
is the dianion of 5,10,15,20-tetrakis-phenyl-porphyrin and TPFPP is the dianion of 5,10,15,20…

A significant number of proteins in both eukaryotes and prokaryotes are known to be post-translationally
modified by the addition of phosphate, serving as a means of rapidly regulating …

The intracellular second messenger deprotonated adenosine 3′,5′-cyclic monophosphate
anion (cAMP-H) − , generated as gaseous species by electrospray ionization (ESI) and …