A decade in the MIST: learnings from investigations of drug metabolites in drug development under the “metabolites in safety testing” regulatory guidance
…, C Funk, CECA Hop, WG Humphreys, F Igarashi… - Drug Metabolism and …, 2018 - ASPET
Since the introduction of metabolites in safety testing (MIST) guidance by the Food and Drug
Administration in 2008, major changes have occurred in the experimental methods for the …
Administration in 2008, major changes have occurred in the experimental methods for the …
[HTML][HTML] A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in …
S Enya, T Ameku, F Igarashi, M Iga, H Kataoka… - Scientific reports, 2014 - nature.com
In insects, the precise timing of moulting and metamorphosis is strictly guided by ecdysteroids
that are synthesised from dietary cholesterol in the prothoracic gland (PG). In the past …
that are synthesised from dietary cholesterol in the prothoracic gland (PG). In the past …
The silkworm glutathione S-transferase gene noppera-bo is required for ecdysteroid biosynthesis and larval development
Insect molting and metamorphosis are tightly controlled by ecdysteroids, which are important
steroid hormones that are synthesized from dietary sterols in the prothoracic gland. One of …
steroid hormones that are synthesized from dietary sterols in the prothoracic gland. One of …
Cholesterol internalization and metabolism in insect prothoracic gland, a steroidogenic organ, via lipoproteins
F Igarashi, MH Ogihara, M Iga, H Kataoka - Steroids, 2018 - Elsevier
Dietary sterols including cholesterol and phytosterols are essential substrates for insect steroid
hormone (ecdysteroid) synthesis in the prothoracic glands (PGs). In the silkworm Bombyx …
hormone (ecdysteroid) synthesis in the prothoracic glands (PGs). In the silkworm Bombyx …
A highly specific and sensitive quantification analysis of the sterols in silkworm larvae by high performance liquid chromatography–atmospheric pressure chemical …
F Igarashi, J Hikiba, MH Ogihara, T Nakaoka… - Analytical …, 2011 - Elsevier
The biochemical quantification of sterols in insects has been difficult because only small
amounts of tissues can be obtained from insect bodies and because sterol metabolites are …
amounts of tissues can be obtained from insect bodies and because sterol metabolites are …
Main contribution of UGT1A1 and CYP2C9 in the metabolism of UR-1102, a novel agent for the treatment of gout
M Yamane, F Igarashi, T Yamauchi, T Nakagawa - Xenobiotica, 2021 - Taylor & Francis
UR-1102, a novel uricosuric agent for treating gout, has been confirmed to exhibit a
pharmacological effect in patients. We clarified its metabolic pathway, estimated the contribution of …
pharmacological effect in patients. We clarified its metabolic pathway, estimated the contribution of …
Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer …
F Igarashi, T Nakagawa, Y Shinohara… - Pharmaceutical …, 2021 - Springer
Purpose The purpose of this research is to analyze non-linear pharmacokinetics of P-glycoprotein
(P-gp) substrates in a cell based assay of a microfluidic device, which might be …
(P-gp) substrates in a cell based assay of a microfluidic device, which might be …
[CITATION][C] Laser Fourier morphometry on cell surface with micro‐spheres bound by means of antigen‐antibody reaction to specific sites assisted by computer …
T Hayashi, Y Yoshimuta, F Igarashi… - … on Form I, 1986 - KTK Scientific Publishers
[CITATION][C] Kore wa minshuto da
I Fumihiko - Jiritsu to kyosei no shimin chushin-gata shakai e, 1996
[CITATION][C] Ohkurashou Kaitairon
F Igarashi - 2010), Seiken. Tokyo: Nihon Keizai Shinbunsha., Kenji …, 1995