The gastrointestinal tract remains the most popular and acceptable route of administration
for drugs. It offers the great advantage of convenience and many compounds are well …

This is the report of the forty-sixth of a series of workshops organised by the European
Centre for the Validation of Alternative methods (ECVAM). ECVAM’s main goal, as defined in …

… vieve Fabre, a professor of American literature at the University of Paris, and Robert O’Meally,
a professor of English and African American Studies at Columbia University, is no …

In previous papers we demonstrated that cyclosporin A (C5A) was specifically oxidized in
rabbit and human liver by cytochrome P-450111A. We therefore anticipated that any drug that …

Cytochrome P450 chemical inhibitors are widely used to define the role of individual
cytochrome P450 isozyme(s) in a metabolism process. In this study, cytochrome P450 isoform-…

This paper presents the results of laboratory tests on the time-dependent behaviour of three
rocks characterized by a high proportion of clay particles. The viscosity of these sedimentary …

Purpose. To determine and compare the relationship between in vivo oral absorption in
humans and the apparent permeability coefficients (P app ) obtained in vitro on two human …

… ο G part is related to drug partitioning, whereas ο G c r o s s i n g is the highest energetic …
The potential well and the ο G c r o s s i n g may be localized in different regions; this very …

Although the multilayered structure of the plant cuticle was discovered many years ago, the
molecular basis of its formation and the functional relevance of the layers are not understood. …

A cytochrome P-450 involved in the metabolism of cyclosporin A (CsA) was isolated and
purified to electrophoretic homogeneity from human liver microsomes of renal transplant donors…