… D., Nathaniel Winer, MD, Gregory Kochak, BS, … Plasma was separated immediately by
centrifugation (1,764 g) and stored frozen at - 30 for analysis. All urine was collected from 2 hr …

A 56‐day pharmacokinetic study of zonisamide was conducted in 24 healthy volunteers.
Steady state was achieved in 29 days including two dose escalations, and in an average of 15 …

… Kochak, PhD,t Sheila Fitzsimmons, AB,t Sherry I. Sanders, AB,* and Richard J. Santen, MD*
… Blood samples were centrifuged at 1200 X g for 1 5 minutes and the plasma was frozen at - …

… Kochak G, Honc F: An improved gas-liquid chromatographic method for the determination
of baclofen in plasma and urine. J Chromatogr 310:319-326, 1984. Knutsson E, Lindblom U, …

The comparative bioavailability and steady state fluctuations resulting from the administration
of Tegretol 200 mg commercial tablets and carbamazepine OROS controlled delivery …

… Borate buffer pH 10 was prepared by dissolving 24.6 g boric acid, 29.8 g potassium
chloride and 14.1 g sodium hydroxide (all obtained from JT Baker) in 1 1 of distilled water. …

In this dose-ranging phase I study, the relationship between in vivo androgen to estrogen
conversion kinetics and plasma concentrations of fadrozole was investigated in …

The pharmacokinetic interaction between pentopril (250 mg) and furosemide (40 mg) was
studied in 12 normal healthy volunteers after oral administration of each drug alone and in …

… For the median dog weight of 17.5 kg used in this study and corresponding average liver
weight of 525 g, 13 the clearance is about 121 mL/min. Oxyphenbutazone is eliminated by …

The pharmacokinetics and cardiovascular effects of nicotine and its major metabolite,
cotinine, were characterized during repeated once-daily application for 5 days of a 30-cm 2 …