The preclinical pharmacology, antitumor activity and toxicity of seven of the more important
amino acid analogs, with antineoplastic activity, is discussed in this review. Three of these …

A series of dinucleotides, analogous to nicotinamide adenine dinucleotide but containing the
five-membered base nucleosides tiazofurin (la), selenazofurin (lb), ribavirin (2), and AICAR …

The pharmacological effects and metabolism of tiazofurin have been compared in the six
transplantable tumors comprising the NCI rodent tumor panel, viz. the P388 leukemia (S); the …

Thiazole-4-carboxamide adenine dinucleotide (TAD), the active metabolite of the oncolytic C-nucleoside
tiazofurin (TR), is susceptible to phosphodiesteratic breakdown by a unique …

2',3'-Dideoxyadenosine (ddAdo) and its deamination product 2',3'-dideoxyinosine (ddIno) (didanosine)
inhibit the replication and infectivity of the human immunodeficiency virus (HIV) in …

Few dermatologic conditions carry as much anxiety and emotional distress as hair loss
resulting from a disease condition such as alopecia areata or as a result of cytotoxic drug …

The toxicity, uptake, and metabolism of the oncolytic nucleoside cyclopentenyl cytosine (CPEC)
have been examined in the Molt-4 line of human lymphoblasts. This compound is known …

In this report, we have compared the uptake, metabolism, and relevant enzymology of a
novel anti-acquired immunodeficiency syndrome drug, 2’-fluoro-2’, 3’-dideoxyarabinosyladenine…

… For all specimens, a 10% emulsified suspension of each stool was clarified by centrifugation
(12,000 g) in RC-5B Sorvall centrifuge (DuPont), and an antibiotic-treated specimen was …

We report the case of a 12-year-old boy with a hypoplastic retroesophageal circumflex right-sided
cervical aortic arch and coarctation. After the incidental finding of a heart murmur when …