Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes

CA Reilly, GS Yost - Drug metabolism reviews, 2006 - Taylor & Francis
… and its analogs are described in detail in Reilly and Yost (Citation2005). These capsaicinoid
analogs used in this … Supernatant fraction after centrifugation at 9000 × g for 30 minutes …

[HTML][HTML] Cytokine responses of human lung cells (BEAS-2B) treated with micron-sized and nanoparticles of metal oxides compared to soil dusts

…, EG Kaser, MM Veranth, M Koch, GS Yost - Particle and fibre …, 2007 - Springer
Background The induction of cytokines by airway cells in vitro has been widely used to assess
the effects of ambient and occupational particles. This study measured cytotoxicity and the …

Quantum mechanically derived AMBER‐compatible heme parameters for various states of the cytochrome P450 catalytic cycle

K Shahrokh, A Orendt, GS Yost… - Journal of …, 2012 - Wiley Online Library
Molecular mechanics (MM) methods are computationally affordable tools for screening
chemical libraries of novel compounds for sites of P450 metabolism. One challenge for MM …

Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors

…, DL Lanza, BA Carr, DJ Crouch, GS Yost - Toxicological …, 2003 - academic.oup.com
… The cells were washed once by centrifugation at 500 g for 5 min and resuspended in the
same buffer. Aliquots of approximately 1 × 10 5 cells/ml were prepared, pelleted by …

Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products

CA Reilly, DJ Crouch, GS Yost - Journal of forensic …, 2001 - asmedigitalcollection.asme.org
g/L versus 13.5 0.1 g/L. Variability in product composition was also observed in products
from different manufacturers that were both labeled as 10% oleoresin capsicum with a rating of …

Mechanisms of 3-methylindole pneumotoxicity

GS Yost - Chemical research in toxicology, 1989 - ACS Publications
A large number of chemicals selectively damage mam-malian lung tissues without significant
toxicity to other organs. The selectivity of these xenobiotic compounds for pulmonary …

Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography–mass spectrometry and liquid chromatography …

CA Reilly, DJ Crouch, GS Yost, AA Fatah - Journal of Chromatography A, 2001 - Elsevier
Sensitive and selective liquid chromatography–mass spectrometry (LC–MS) and liquid
chromatography–tandem mass spectrometry (LC–MS–MS) methods for the analysis of capsaicin, …

Human lung epithelial cells express a functional cold-sensing TRPM8 variant

AS Sabnis, M Shadid, GS Yost… - American journal of …, 2008 - atsjournals.org
Several transient receptor potential (TRP) ion channels sense and respond to changes in
ambient temperature. Chemical agonists of TRP channels, including menthol and capsaicin, …

Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells

…, DE Moody, DJ Crouch, GS Yost - Chemical research in …, 2003 - ACS Publications
Capsaicin is a common dietary constituent and a popular homeopathic treatment for chronic
pain. Exposure to capsaicin has been shown to cause various dose-dependent acute …

Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity …

…, RW Hughen, AR Light, GS Yost… - Chemical research in …, 2011 - ACS Publications
Inhalation of environmental particulate matter (PM) is correlated with adverse health effects
in humans, but gene products that couple detection with cellular responses, and the specific …