User profiles for G. M. Meno-Tetang

Guy Meno-Tetang

AstraZeneca
Verified email at astrazeneca.com
Cited by 914

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2 [2-(-4-octylphenyl) ethyl] propane-1, 3-diol hydrochloride) in rats after oral and intravenous …

GML Meno-Tetang, H Li, S Mis, N Pyszczynski… - Drug Metabolism and …, 2006 - ASPET
… This work was supported by Novartis Pharma AG and in part by Grant GM 24211 from the
National Institutes of Health. The liquid chromatograph/tandem mass spectrometer was …

[PDF][PDF] Efficacy of Epratuzumab, an Anti‐CD 22 Monoclonal IgG Antibody, in Systemic Lupus Erythematosus Patients With Associated Sjögren's Syndrome: Post Hoc …

…, DM Goldenberg, G MenoTetang… - Arthritis & …, 2018 - Wiley Online Library
… Defined as a C3 level of <0.9 gm/liter or a C4 level of <180 mg/liter. ¶ Defined according
to the rules of the central laboratory, which may have varied across treatment regions. …

[HTML][HTML] Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

…, J Bullman, D Krull, A Berges, B Abila, G Meno-Tetang… - PloS one, 2014 - journals.plos.org
<p>The neurite outgrowth inhibitor, Nogo-A, has been shown to be overexpressed in
skeletal muscle in amyotrophic lateral sclerosis (ALS); it is both a potential biomarker and …

A translational platform PBPK model for antibody disposition in the brain

HY Chang, S Wu, G Meno-Tetang, DK Shah - Journal of pharmacokinetics …, 2019 - Springer
In this manuscript, we have presented the development of a novel platform physiologically-based
pharmacokinetic (PBPK) model to characterize brain disposition of mAbs in the mouse, …

Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving non-linear tissue uptake

R Laplanche, GML Meno-Tetang, R Kawai - Journal of pharmacokinetics …, 2007 - Springer
Everolimus is a novel macrolide immunosuppressant developed for the prophylaxis of
allogeneic renal or cardiac transplant rejection. Treatments with immunosuppressants are often …

Effects of oral prasterone (dehydroepiandrosterone) on single‐dose pharmacokinetics of oral prednisone and cortisol suppression in normal women

GML MenoTetang, RA Blum… - The Journal of …, 2001 - Wiley Online Library
This study sought to determine effects of multiple dosing of prasterone (DHEA,
dehydroepiandrosterone) on the pharmacokinetics of prednisolone and endogenous cortisol …

Synergistic interaction between dehydroepiandrosterone and prednisolone in the inhibition of rat lymphocyte proliferation

GML Meno-Tetang, YY Hon… - Immunopharmacology and …, 1996 - Taylor & Francis
The interaction between dehydroepiandrosterone (DHEA) and prednisolone (PD) in the
inhibition of rat lymphocyte proliferation was evaluated. The in vitro proliferative response of …

Pharmacokinetic and pharmacodynamic interactions between dehydroepiandrosterone and prednisolone in the rat

GML Meno-Tetang, YY Hon, S Van Wart… - Drug metabolism and …, 1999 - degruyter.com
The effects of multiple-dosing with dehydroepiandrosterone sulfate (DHEA-SO4) on the
pharmacokinetics and pharmacodynamics of prednisolone were examined. Prednisolone (25 mg…

Influence of gender on prednisolone effects on whole blood T‐cell deactivation and trafficking in rats

GML MenoTetang, JVS Gobburu… - Journal of …, 1999 - Wiley Online Library
Prednisolone (5 mg/kg intravenous) was administered to adrenalectomized male and
female Sprague‐Dawley rats (250–350 g) to assess the effects of gender on disposition and …

PHARMACOKINETIC/PHARMACODYNAMIC (PK/PD) MODELING OF THE TRAFFICKING EFFECTS OF FTY720 ON RAT IMMUNE CELLS.: Abstract# 305 Poster …

GM Meno-Tetang, K Chiba, N Arima, R Kawai… - …, 2000 - journals.lww.com
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