Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease—therapeutic aspects
As a fully differentiated organ, our brain is very sensitive to cumulative oxidative damage of
proteins, lipids, and DNA occurring during normal aging because of its high energy …
proteins, lipids, and DNA occurring during normal aging because of its high energy …
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease ( AD ). Some reports, mostly retrospective epidemiological studies, have observed a …
disease ( AD ). Some reports, mostly retrospective epidemiological studies, have observed a …
Statins and neuroprotection: a prescription to move the field forward
WG Wood, GP Eckert, U Igbavboa… - Annals of the New York …, 2010 - Wiley Online Library
… Statins are substrates for P-gp and this transporter may play a role in statin efflux from cells.
P-gp is a … P-gp could act as a transporter both at the blood-brain barrier and neuronal cells. …
P-gp is a … P-gp could act as a transporter both at the blood-brain barrier and neuronal cells. …
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation
…, A Occhipinti, S Mai, M Jendrach, GP Eckert… - Antioxidants & redox …, 2012 - liebertpub.com
… 39 Müller WEEckert AKurz CEckert GPLeuner KMitochondrial dysfunction: common final
pathway in brain aging and Alzheimer's disease—therapeutic aspectsMol Neurobiol41159171…
pathway in brain aging and Alzheimer's disease—therapeutic aspectsMol Neurobiol41159171…
[HTML][HTML] Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease
Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration
in Alzheimer's disease (AD). This protein is an amphipathic molecule that perturbs …
in Alzheimer's disease (AD). This protein is an amphipathic molecule that perturbs …
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex
LN Johnson-Anuna, GP Eckert, JH Keller… - … of Pharmacology and …, 2005 - ASPET
Statins have been reported to lower the risk of developing Alzheimer's disease; however, the
mechanism of this potentially important neuroprotective action is not understood. Lowering …
mechanism of this potentially important neuroprotective action is not understood. Lowering …
Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo
Elevated oxidative and nitrosative stress both impair the integrity and functioning of brain
tissue, especially in aging. As long-term intake of plant foods rich in antioxidant phenolics, such …
tissue, especially in aging. As long-term intake of plant foods rich in antioxidant phenolics, such …
Statin effects on cholesterol micro-domains in brain plasma membranes
C Kirsch, GP Eckert, WE Mueller - Biochemical pharmacology, 2003 - Elsevier
Recent epidemiological studies revealed inhibitors of the hydroxymethylglutaryl-coenzyme
A reductase, so-called statins, to be effective in lowering the prevalence of Alzheimer’s …
A reductase, so-called statins, to be effective in lowering the prevalence of Alzheimer’s …
Isoprenoids, small GTPases and Alzheimer's disease
The mevalonate pathway is a crucial metabolic pathway for most eukaryotic cells. Cholesterol
is a highly recognized product of this pathway but growing interest is being given to the …
is a highly recognized product of this pathway but growing interest is being given to the …
[HTML][HTML] Regulation of the brain isoprenoids farnesyl-and geranylgeranylpyrophosphate is altered in male Alzheimer patients
GP Eckert, GP Hooff, DM Strandjord, U Igbavboa… - Neurobiology of …, 2009 - Elsevier
Post-translational modification of small GTPases by farnesyl- (FPP) and
geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential …
geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential …