Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease—therapeutic aspects

WE Müller, A Eckert, C Kurz, GP Eckert… - Molecular neurobiology, 2010 - Springer
As a fully differentiated organ, our brain is very sensitive to cumulative oxidative damage of
proteins, lipids, and DNA occurring during normal aging because of its high energy …

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

…, L Li, WE Müller, GP Eckert - Journal of …, 2014 - Wiley Online Library
High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease ( AD ). Some reports, mostly retrospective epidemiological studies, have observed a …

Statins and neuroprotection: a prescription to move the field forward

WG Wood, GP Eckert, U Igbavboa… - Annals of the New York …, 2010 - Wiley Online Library
… Statins are substrates for P-gp and this transporter may play a role in statin efflux from cells.
P-gp is a … P-gp could act as a transporter both at the blood-brain barrier and neuronal cells. …

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

…, A Occhipinti, S Mai, M Jendrach, GP Eckert… - Antioxidants & redox …, 2012 - liebertpub.com
… 39 Müller WEEckert AKurz CEckert GPLeuner KMitochondrial dysfunction: common final
pathway in brain aging and Alzheimer's disease—therapeutic aspectsMol Neurobiol41159171…

[HTML][HTML] Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease

WG Wood, GP Eckert, U Igbavboa, WE Müller - Biochimica et Biophysica …, 2003 - Elsevier
Amyloid beta-protein (Aβ) is thought to be one of the primary factors causing neurodegeneration
in Alzheimer's disease (AD). This protein is an amphipathic molecule that perturbs …

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

LN Johnson-Anuna, GP Eckert, JH Keller… - … of Pharmacology and …, 2005 - ASPET
Statins have been reported to lower the risk of developing Alzheimer's disease; however, the
mechanism of this potentially important neuroprotective action is not understood. Lowering …

Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo

…, F Visioli, P Bogani, WE Müller, GP Eckert - Journal of agricultural …, 2007 - ACS Publications
Elevated oxidative and nitrosative stress both impair the integrity and functioning of brain
tissue, especially in aging. As long-term intake of plant foods rich in antioxidant phenolics, such …

Statin effects on cholesterol micro-domains in brain plasma membranes

C Kirsch, GP Eckert, WE Mueller - Biochemical pharmacology, 2003 - Elsevier
Recent epidemiological studies revealed inhibitors of the hydroxymethylglutaryl-coenzyme
A reductase, so-called statins, to be effective in lowering the prevalence of Alzheimer’s …

Isoprenoids, small GTPases and Alzheimer's disease

GP Hooff, WG Wood, WE Müller, GP Eckert - Biochimica et Biophysica Acta …, 2010 - Elsevier
The mevalonate pathway is a crucial metabolic pathway for most eukaryotic cells. Cholesterol
is a highly recognized product of this pathway but growing interest is being given to the …

[HTML][HTML] Regulation of the brain isoprenoids farnesyl-and geranylgeranylpyrophosphate is altered in male Alzheimer patients

GP Eckert, GP Hooff, DM Strandjord, U Igbavboa… - Neurobiology of …, 2009 - Elsevier
Post-translational modification of small GTPases by farnesyl- (FPP) and
geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential …