Surprisingly, neither the precise pharmacological effect nor the toxicological profile is usually
established for food components. Carotenoids are no exception in this regard. Only limited …

Chronic inflammation has been recognized as a contributing factor in the pathogenesis of
lung cancer. In this process, reactive oxygen species released by neutrophils may play an …

The therapeutic effect of ebselen has been linked to its peroxi-dase activity. In the present
study, the peroxidase activity of ebselen toward H202 with the endogenous thiols GSH and …

Respirable quartz has been classified as a human lung carcinogen (IARC, 1997). However,
the mechanisms involved in quartz-induced carcinogenesis remain unclear. The aim of the …

… Guido R Haenen: analysis and interpretation of data; drafting of the manuscript. Bjorn
Winkens: statistical analysis; critical revision of the manuscript for important intellectual content. …

We investigated the effects of smoking-induced oxidative stress in healthy volunteers (21
smokers versus 24 non-smokers) by quantifying various markers of oxidative DNA damage and …

Objective— Advanced murine and human plaques are hypoxic, but it remains unclear
whether plaque hypoxia is causally related to atherogenesis. Here, we test the hypothesis that …

… with VO2 and VCO2 in liters per minute and oxidation rates in grams per minute. Total work
to be performed during the time trial was calculated to be 1 h if subjects cycled at 60% Wmax …

The use of paracetamol as tool to determine gastric emptying was evaluated in a cross over
study. Twelve healthy volunteers were included and each of them consumed two low and …

Objective Beta-carotene has been shown to exhibit a good radical-trapping antioxidant
activity in vitro. We were interested to see if dietary beta-carotene in combination with various …