… Kinetic analysis of the in vivo tissue distribution of the granulocyte colony stimulating factor
(G-… clearance might be due to the downregulation of G-CSF receptors on the cell surface.123 …

There are significant differences in the pharmacokinetic properties of inhaled corticosteroids
currently used in medical practice. All are rapidly cleared from the body but they show …

Objective: Omalizumab (Xolair ), is a recombinant humanised monoclonal anti-immunoglobulin
E (IgE) antibody, for the treatment of allergic asthma. This review describes how the …

… an unrealistic 682.5 µmol/min or >5 g/h (or >128 g/24 hours).[63] … g/day) has been shown
to increase urinary creatine levels, and after more than 3 days of loading at 4 × 5 g/day (20 g…

The Biopharmaceutics Classification System (BCS), developed in the 1990s for oral
immediate release drugs, is utilized by R&D scientists and regulators to streamline product …

Bronchial asthma and allergic rhinitis are among the most common diseases of modern society
and to an increasing degree a major cause of illness, hospitalization, loss of productivity, …

The pharmacodynamics of three corticosteroids were investigated after intravenous
administration of the phosphate esters of methylprednisolone, dexamethasone, and triamcinolone …

Glucocorticoids are important anti-inflammatory substances that play a major role in the
treatment of local and systemic inflammations. Knowledge about the pharmacokinetics and …

… Chloromethylchlorosulfate (4.75 g, 0.029 mol) in methylene … g. The product was crystallized
from hot acetone (100 ml). … and Hochhaus G.: Receptor binding affinities of commercial …

Glucocorticoids are predominantly prescribed in asthma therapy as aerosols to achieve high
pulmonary effects with reduced systemic spill‐over and pronounced pulmonary selectivity. …