How do we acquire immune tolerance against food microorganisms and commensal bacteria
that constitute the intestinal microbiota? We investigated this by stimulating the immune …

Resistant starch (RS) is highly fermentable by microbiota in the colon, resulting in the
production of SCFAs. RS is thought to mediate a large proportion of its health benefits, including …

Legume GRAS (GAI, RGA, SCR)-type transcription factors NODULATION SIGNALING
PATHWAY1 (NSP1) and NSP2 are essential for rhizobium Nod factor-induced nodulation. Both …

Background Obesity and insulin resistance are two major risk factors underlying the metabolic
syndrome. The development of these metabolic disorders is frequently studied, but mainly …

The rapid increase of ~omics datasets generated by microarray, mass spectrometry and
next generation sequencing technologies requires an integrated platform that can combine …

Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled,
Turkish, and cafetière coffee, is the most potent cholesterol-elevating compound known in the …

Background Folate and its synthetic form folic acid function as donor of one-carbon units
and have been, together with other B-vitamins, implicated in programming of epigenetic …

The peroxisome proliferator-activated receptor alpha (PPARα) is a fatty acid-activated
transcription factor that governs a variety of biological processes. Little is known about the role of …

Hepatobiliary transport of endogenous and exogenous compounds is mediated by the
coordinated action of multiple transport systems present at the sinusoidal (basolateral) and …

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet
the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the …