… However, in a more recent study from our laboratory (GJ Mannering, LB Deloria, VS Abbott
… In a recent study (SK Kuwahara & GJ Mannering, unpublished data), we showed that poly IC…

Cytochrome P-450-dependent monooxygenase activities and cytochrome P-450 levels were
depressed in hepatic microsomes from rats treated with 12 interferon inducing agents of …

Hepatic microsomes N-demethylate ethylmorphine and 3-methyl-4-methylaminoazobenzene
(3-MMAB). The administration of phenobarbital to male rats stimulates the N-demethylation …

The administration of 3,4-benzpyrene, 3-methylcholanthrene, or phenobarbital to male rats
stimulated the N-demethylation of 3-methyl-4-methylaminoazobenzene (3-MMAB) by hepatic …

SKF 525-A and ten congeners were incubated with Imepatic microsomes, and all were
found to be N-dealkylated. The kinetics of time inhibition of time N-demetimylation of …

Two-substrate kinetics was employed to show that more than one microsomal system functions
in the dealkylation of drugs. Evidence is also presented to show that in some dealkylation …

Results on the mechanism of inactivation of liver and erythrocyte catalase activity by 3-amino-1,2,4-triazole
(AT) have been presented. Hydrogen peroxide generated enzymatically, as …

The controversy as to which enzyme system is primarily responsible for the first step in the
oxidation of methanol by mammals can be said to have originated with the isolation of …

Previous studies from our laboratory have shown that a variety of interferon-inducing agents
depress cytochrome P-450-dependent monooxygenase systems when administered to rats. …

The duration and intensity of drug action depend not only on the dose of the drug but also
on the rates at which drugs are transformed to products that can be excreted readily by the …