… in G 1 to S transition. Whereas this mechanism has been proposed to contribute to G 1 arrest
… might protect cells from DOX because the G 1 block facilitates DNA repair before the cells …

The discipline of Cardio-Oncology has seen tremendous growth over the past decade. It is
devoted to the cardiovascular (CV) care of the cancer patient, especially to the mitigation and …

Anthracyclines remain among the most widely prescribed and effective anticancer agents.
Unfortunately, life-threatening cardiotoxicity continues to compromise their usefulness. …

… Catalase was separated from the antioxidant thymol by gel chromatography on Sephadex
G-25. Following chromatography the enzyme activity was measured by the method of Beers …

F 2 -isoprostanes are bioactive prostaglandin (PG) -like compounds that are produced from
arachidonic acid through a nonenzymatic process of lipid peroxidation catalyzed by oxygen …

… Minotti, G. (1989) Adriamycin dependent release of iron from microsomal membranes. Arch.
… Minotti, G. (1990) NADPH and adriamycin dependent microsomal release of iron and lipid …

… Gel-chromatography on Sephadex G-25, equilibrated with 0.3 M NaC1, pH 7.0, was used to
… Minotti, G.; Aust, SD The requirement for ferric in the initiation of lipid peroxidation by ferrous …

… Data taken in part from Minotti and Aust [16]. Incubations contained microsomai phospholipid
llposomes (1 ~mot lipid phosphate/ml), 0.33 mM xanthine and ADP-Fe )ק (0.11 mM ADP/…

… NaCl was chromatographed on Chelex-100 to remove contaminating metals, and catalase
was chromatographed on Sephadex G-25 to remove the antioxidant thymol and other …

Abstract Changes in iron homeostasis have been implicated in cardiotoxicity induced by the
anticancer anthracycline doxorubicin (DOX). Certain products of DOX metabolism, like the …