Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites
…, KH Leung, GA Doss, JR Strauss, GY Kwei… - Drug Metabolism and …, 1999 - ASPET
The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal
hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three …
hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three …
[PDF][PDF] Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
JH Lin, M Chiba, SK Balani, IW Chen, GY Kwei… - Drug metabolism and …, 1996 - Citeseer
Indinavir, a potent and specific inhibitor of human immunodeficiency virus protease, is
undergoing clinical investigation for the treatment of acquired immunodeficiency syndrome. The …
undergoing clinical investigation for the treatment of acquired immunodeficiency syndrome. The …
Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein
GY Kwei, RF Alvaro, Q Chen, HJ Jenkins, C Hop… - Drug Metabolism and …, 1999 - ASPET
The pharmacokinetics and hepatic metabolism of [ 3 H] ivermectin (IVM) and [ 3 H]cyclosporin
A (CSA) were investigated in a subpopulation of the CF-1 mouse stock naturally deficient …
A (CSA) were investigated in a subpopulation of the CF-1 mouse stock naturally deficient …
Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism
W Tang, RA Stearns, GY Kwei, SA Iliff, RR Miller… - … of Pharmacology and …, 1999 - ASPET
The cytochrome P-450 (CYP)3A4-mediated metabolism of diclofenac is stimulated in vitro
by quinidine. A similar effect is observed in incubations with monkey liver microsomes. We …
by quinidine. A similar effect is observed in incubations with monkey liver microsomes. We …
The liver plays a central role in the mechanism of chemical carcinogenesis due to polycyclic aromatic hydrocarbons
KL Wall, W Gao, JM Koppele, GY Kwei… - …, 1991 - academic.oup.com
The important problem of whether metabolites and DNA adducts from benzo[a]pyrene (B[a]P)
originate in the liver or target tissues was assessed using orthotopic liver transplantation. …
originate in the liver or target tissues was assessed using orthotopic liver transplantation. …
Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein
S Kumar, GY Kwei, GK Poon, SA Iliff, Y Wang… - … of Pharmacology and …, 2003 - ASPET
The mechanisms of pharmacokinetic interactions of a novel anti-human immunodeficiency
virus (anti-HIV-1) antagonist of chemokine receptor 5 (CCR5) [2-(R)-[N-methyl-N-(1-(R)-3-(S)-(…
virus (anti-HIV-1) antagonist of chemokine receptor 5 (CCR5) [2-(R)-[N-methyl-N-(1-(R)-3-(S)-(…
Antagonists of human CCR5 receptor containing 4-(pyrazolyl) piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment
…, J Di Salvo, K Lyons, JV Pivnichny, GY Kwei… - Bioorganic & medicinal …, 2004 - Elsevier
Extensive SAR studies in our benzylpyrazole series of CCR5 antagonists have shown that
both lipophilic and hydrophilic substituents on the phenyl of the benzyl group increase …
both lipophilic and hydrophilic substituents on the phenyl of the benzyl group increase …
Antagonists of human CCR5 receptor containing 4-(pyrazolyl) piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains
…, SL Gould, JA DeMartino, SJ Siciliano, GY Kwei… - Bioorganic & medicinal …, 2004 - Elsevier
Replacement of the flexible connecting chains between the piperidine moiety and an aromatic
group in previous CCR5 antagonists with heterocycles, such as pyrazole and isoxazole, …
group in previous CCR5 antagonists with heterocycles, such as pyrazole and isoxazole, …
Antagonists of human CCR5 receptor containing 4-(pyrazolyl) piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds
…, SJ Siciliano, K Lyons, JV Pivnichny, GY Kwei… - Bioorganic & medicinal …, 2004 - Elsevier
Modifications of the alkyl acetic acid portion and the phenyl on pyrrolidine in our lead
pyrazole compound 1 afforded the isopropyl compound 9. This compound is a potent CCR5 …
pyrazole compound 1 afforded the isopropyl compound 9. This compound is a potent CCR5 …
Regiospecific intestinal absorption of the HIV protease inhibitor L-735,524 in beagle dogs
GY Kwei, LB Novak, LA Hettrick, ER Reiss… - Pharmaceutical …, 1995 - Springer
Purpose. To evaluate regional intestinal absorption and the feasibility of sustained release
dosage form development for an HIV protease inhibitor, L-735,524. Methods. L-735,524 free …
dosage form development for an HIV protease inhibitor, L-735,524. Methods. L-735,524 free …