An integrated molecular modeling system for designing and studying organic and bioorganic
molecules and their molecular complexes using molecular mechanics is described. The …

Importance Evidence about the efficacy of laparoscopic resection of rectal cancer is
incomplete, particularly for patients with more advanced-stage disease. Objective To determine …

Purpose Fluorouracil/leucovorin as the sole therapy for metastatic colorectal cancer (CRC)
provides an overall survival of 8 to 12 months. With an increase in surgical resections of …

An internal coordinate, random-search method for finding the low-energy conformations of
organic molecules is described. The search is biased toward the low-energy regions of …

Background Adequate lymph node evaluation for cancer involvement is important for prognosis
and treatment of patients with colon cancer. The number of lymph nodes evaluated may …

Importance The overall incidence of colorectal cancer (CRC) has been decreasing since
1998 but there has been an apparent increase in the incidence of CRC in young adults. …

As a test of the effectiveness of various methods for searching the conformational space of
highly flexible molecules, we conducted a series of conformational searches on …

Purpose Neoadjuvant chemoradiotherapy for rectal cancer is associated with improved local
control and may result in complete tumor response. Associations between tumor response …

Cellular entry of human immunodeficiency virus type 1 (HIV-1) requires binding to both CD4
(ref. 1, 2) and to one of the chemokine receptors recently discovered to act as coreceptors 3–…

BACKGROUND The objective of this study was to identify predictive factors for pathologic
complete response and tumor downstaging after preoperative chemoradiation for rectal cancer…