Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain
…, B Van De Water, E De Heer, GJ Mulder… - … of Pharmacology and …, 1997 - ASPET
Cisplatin-induced nephrotoxicity was studied in porcine proximal tubular cells, focusing on
the relationship between mitochondrial damage, reactive oxygen species (ROS) and cell …
the relationship between mitochondrial damage, reactive oxygen species (ROS) and cell …
The UDP glucuronosyltransferase gene super family: suggested nomenclature based on evolutionary divergence
A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based
on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species …
on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species …
Glucuronidation and its role in regulation of biological activity of drugs
GJ Mulder - Annual review of pharmacology and toxicology, 1992 - annualreviews.org
Glucuronidation is a major drug-metabolizing reaction. It involves the trans fer of the glucuronic
acid group from UDP-glucuronic acid (UDPGlucA) to an acceptor group on a substrate. …
acid group from UDP-glucuronic acid (UDPGlucA) to an acceptor group on a substrate. …
[BOOK][B] Conjugation reactions in drug metabolism: an integrated approach
GJ Mulder - 1990 - books.google.com
This text investigates the molecular biology of conjugation, and the subsequent activity of
the transfered genes" in vivo". Conjugation may be very important when considering …
the transfered genes" in vivo". Conjugation may be very important when considering …
Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-l-methyl-6-phenyUmidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues
KR Kaderlik, RF Minchin, GJ Mulder, KF Ilett… - …, 1994 - academic.oup.com
The food-borne mutagen 2-amino-l-methyl-6-phenylimidazo[ 4,5-b]pyridine (PhIP) induces
tumors in colon of male rats and has been implicated in the etiology of human cancers, …
tumors in colon of male rats and has been implicated in the etiology of human cancers, …
[HTML][HTML] Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells
M Huigsloot, IB Tijdens, GJ Mulder… - Journal of Biological …, 2002 - ASBMB
Various anticancer drugs cause mitochondrial perturbations in association with apoptosis.
Here we investigated the involvement of caspase- and Bcl-2-dependent pathways in …
Here we investigated the involvement of caspase- and Bcl-2-dependent pathways in …
Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes: The role of saturation of …
…, I Halsema, E Scholtens, M Knippers, GJ Mulder - Biochemical …, 1981 - Elsevier
The role of enzyme-kinetic parameters of sulfotransferase and UDP-glucuronyltransferase
in the balance between sulfation and glucuronidation of various phenolic substrates was …
in the balance between sulfation and glucuronidation of various phenolic substrates was …
Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N, O-sulfonation in chemical carcinogenesis of aromatic …
GJ Mulder, JH Meerman - Environmental health perspectives, 1983 - ehp.niehs.nih.gov
Aromatic amines can be metabolized by N-acetylation and N-hydroxylation to hydroxamic
acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide …
acids; these subsequently are conjugated to form the N,O-sulfonate and N,O-glucuronide …
Glutathione conjugates and their synthetic derivatives as inhibitors of glutathione-dependent enzymes involved in cancer and drug resistance
D Burg, GJ Mulder - Drug metabolism reviews, 2002 - Taylor & Francis
Alterations in levels of glutathione (GSH) and glutathione-dependent enzymes have been
implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, …
implicated in cancer and multidrug resistance of tumor cells. The activity of a number of these, …
p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.
HE van Gijssel, CB Maassen, GJ Mulder… - …, 1997 - academic.oup.com
… lines have shown that p53 is involved in the transcriptional Gerard J.Mulder and John HN…
and Högberg,J. (1995) GST-P-positive hepatocytes isolated from rats bearing enzyme-altered …
and Högberg,J. (1995) GST-P-positive hepatocytes isolated from rats bearing enzyme-altered …