NN, dimethyl- (DMF) and NN, diethyl-formamide (DEF) are two hepatotoxic solvents, whose
metabolism has not been investigated in humans. To identify the P450 isoforms involved in …

Cytochrome P450 (CYP) enzymes of nasal tissue are relatively resistant to induction by
classical inducers. In the present study, the effects of starvation on the expression of CYP1A, 2A, …

Western blot analyses of liver microsomes from 13 male and 12 female monkeys demonstrated
that in each sample a variable amount of a cytochrome P450 (P450) protein, likely …

Methyl t-butyl ether (MTBE) and ethyl t-butyl ether (ETBE) are commonly used in unleaded
gasoline to increase the oxygen content of fuel and to reduce carbon monoxide emissions …

The epoxidation of 1-hexene (1a) and 2-methyl-1-hexene (1b), two hydrocarbons present in
the ambient air as pollutants, is catalyzed by some human and rat P450 enzymes. The …

The stereochemical course of the biotransformation of isoprene by liver enzymes from control
and induced rats has been determined. Between the two primarily formed metabolites, 2-…

The induction of a variety of drug-metabolizing enzymes by six anthraquinones (AQs) has
been investigated in the liver and small intestine of rat. In the liver, the intragastric …

Three constitutive forms of cytochrome P-450 (P-450s) were isolated from olfactory microsomes
of cattle. The purified P-450s, designated P-450bov1, P-450bov2 and P-450bov3, were …

N,N-Diethylformamide (DEF) is a hepatotoxic polar solvent in which metabolism has not been
investigated. In this study we examined the following: (a) the oxidative metabolism of DEF …

The stereochemical course of the biotransformation of 4-vinylcyclohexene (VCH, 1) by liver
microsomes from male and female control and induced rats and purified rat P450 2B1 and …