Oxidative stress in mammalian cells is an inevitable consequence of their aerobic
metabolism. Oxidants produce modifications to proteins leading to loss of function (or gain of …

Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by
classical Michaelis-Menten kinetic parameters (eg, K m andV max ), which are usually …

Objective Skin ageing is a multifactorial process involving formation of reactive oxygen species,
consecutive inflammation with reduced epidermal and dermal cell viability and resulting …

Seven dog cytochromes P450 (P450s) were heterologously expressed in baculovirus-Sf21
insect cells. Of all enzymes examined, CYP1A1 exhibited high 7-ethoxyresorufin O-…

Highly oxidized protein aggregates accumulating in the brain during neurodegenerative
diseases are often surrounded by microglia. Most of the microglial cells surrounding these …

Objective. Inflamed tissues are usually characterized by low oxygen levels. We investigated
whether pathophysiological hypoxia (pO 2 < 1%) as found in the rheumatoid synovium …

Oxidative stress is involved in a number of neurological disorders, including the neurotoxic
effects of ethanol. Recent studies have described a neuroprotective potential of α-lipoic acid (…

Oxidative stress is supposed to play an important role in demyelinating diseases.
Oligodendrocytes are the myelin-forming cells in the brain and are highly susceptible to oxidative …

Oxidative stress plays an important role in cell death associated with many diseases. In the
present study, concentration-dependence of hydrogen peroxide on rat pheochromocytoma (…

Health problems associated with the amount of air pollutants are increasing worldwide.
Pollution damages not only the lungs; it also has an impact on skin health and is co-responsible …