User profiles for Guangji Wang
Guangji WangChina Pharmaceutical University Verified email at stu.cpu.edu.cn Cited by 22985 |
[PDF][PDF] Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis
Cholestasis is a common complication of sepsis, and the increased plasma levels of bile
acids are predictive of sepsis-associated mortality. However, the exact mechanism by which …
acids are predictive of sepsis-associated mortality. However, the exact mechanism by which …
Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
Cytochrome P450 (CYP) 3A4 is the most abundant enzyme of CYPs in the liver and gut that
metabolizes approximately 50% currently available drugs. A number of important drugs …
metabolizes approximately 50% currently available drugs. A number of important drugs …
Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes
The potential for herb-drug interactions has recently received greater attention worldwide,
considering the fact that the use of herbal products becomes more and more widespread. The …
considering the fact that the use of herbal products becomes more and more widespread. The …
Gut microbial metabolites of aromatic amino acids as signals in host–microbe interplay
Y Liu, Y Hou, G Wang, X Zheng, H Hao - Trends in Endocrinology & …, 2020 - cell.com
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …
Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies
Glucagon-like peptide (GLP)-1 is a potent glucose-dependent insulinotropic gut hormone
released from intestinal L cells. Our previous studies showed that berberine increased GLP-1 …
released from intestinal L cells. Our previous studies showed that berberine increased GLP-1 …
Differences in metabolite profile between blood plasma and serum
In metabolomic research, blood plasma and serum have been considered to possess similar
compositions and properties. Their perceived equivalence has resulted in researchers …
compositions and properties. Their perceived equivalence has resulted in researchers …
Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20 (S)‐ginsenoside Rh2 in MCF‐7/Adr cells
BACKGROUND AND PURPOSE Intracellular pharmacokinetics of anticancer drugs in multi‐drug
resistance (MDR) cancer cells is hugely important in the evaluation and improvement …
resistance (MDR) cancer cells is hugely important in the evaluation and improvement …
[HTML][HTML] Herbal drug discovery for the treatment of nonalcoholic fatty liver disease
Few medications are available for meeting the increasing disease burden of nonalcoholic
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH). …
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH). …
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
Lactylation was initially discovered on human histones. Given its nascence, its occurrence
on nonhistone proteins and downstream functional consequences remain elusive. Here we …
on nonhistone proteins and downstream functional consequences remain elusive. Here we …
Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a …
Although the current literature has recorded many reports of identifying components from
herbal preparations, all of them were largely limited to target components. This paper provides …
herbal preparations, all of them were largely limited to target components. This paper provides …