User profiles for Guangji Wang

Guangji Wang

China Pharmaceutical University
Verified email at stu.cpu.edu.cn
Cited by 22985

[PDF][PDF] Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis

…, C Jiang, Y Che, S Zhang, S Takahashi, G Wang… - Cell metabolism, 2017 - cell.com
Cholestasis is a common complication of sepsis, and the increased plasma levels of bile
acids are predictive of sepsis-associated mortality. However, the exact mechanism by which …

Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring

…, CC Xue, XQ Yu, C Li, G Wang - Therapeutic drug …, 2007 - journals.lww.com
Cytochrome P450 (CYP) 3A4 is the most abundant enzyme of CYPs in the liver and gut that
metabolizes approximately 50% currently available drugs. A number of important drugs …

Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes

…, J Sun, A Jiye, H Hao, Y Peng, H Ai, G Wang - Drug Metabolism and …, 2008 - ASPET
The potential for herb-drug interactions has recently received greater attention worldwide,
considering the fact that the use of herbal products becomes more and more widespread. The …

Gut microbial metabolites of aromatic amino acids as signals in host–microbe interplay

Y Liu, Y Hou, G Wang, X Zheng, H Hao - Trends in Endocrinology & …, 2020 - cell.com
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …

Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro studies

…, L Liu, X Wang, X Liu, X Liu, L Xie, G Wang - Biochemical …, 2010 - Elsevier
Glucagon-like peptide (GLP)-1 is a potent glucose-dependent insulinotropic gut hormone
released from intestinal L cells. Our previous studies showed that berberine increased GLP-1 …

Differences in metabolite profile between blood plasma and serum

L Liu, J Aa, G Wang, B Yan, Y Zhang, X Wang… - Analytical …, 2010 - Elsevier
In metabolomic research, blood plasma and serum have been considered to possess similar
compositions and properties. Their perceived equivalence has resulted in researchers …

Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20 (S)‐ginsenoside Rh2 in MCF‐7/Adr cells

…, G Hao, Y Sun, J Sun, Y Peng, G Wang - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Intracellular pharmacokinetics of anticancer drugs in multi‐drug
resistance (MDR) cancer cells is hugely important in the evaluation and improvement …

[HTML][HTML] Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

T Yan, N Yan, P Wang, Y Xia, H Hao, G Wang… - … Pharmaceutica Sinica B, 2020 - Elsevier
Few medications are available for meeting the increasing disease burden of nonalcoholic
fatty liver disease (NAFLD) and its progressive stage, nonalcoholic steatohepatitis (NASH). …

Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome

…, X Wang, C Shao, L Lv, G Wang, R Tan, N Wang… - Nature …, 2022 - nature.com
Lactylation was initially discovered on human histones. Given its nascence, its occurrence
on nonhistone proteins and downstream functional consequences remain elusive. Here we …

Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a …

H Hao, N Cui, G Wang, B Xiang, Y Liang, X Xu… - Analytical …, 2008 - ACS Publications
Although the current literature has recorded many reports of identifying components from
herbal preparations, all of them were largely limited to target components. This paper provides …