Human embryonic and induced pluripotent stem cell-derived hepatocytes (hESC-Hep and
hiPSC-Hep) have the potential to provide relevant human in vitro model systems for toxicity …

Human pluripotent stem cells (hPSC) have the potential to become important tools for the
establishment of new models for in vitro drug testing of, for example, toxicity and …

Doxorubicin is a chemotherapeutic agent indicated for the treatment of a variety of cancer
types, including leukaemia, lymphomas, and many solid tumours. The use of doxorubicin is, …

Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic
drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, …

Purpose We investigated if early intensive care unit (ICU) scoring with the Simplified Acute
Physiology Score (SAPS 3) could be improved using artificial neural networks (ANNs). …

As the conventional approach to assess the potential of a chemical to cause cancer in
humans still includes the 2-year rodent carcinogenicity bioassay, development of alternative …

Tissue engineering is a promising methodology to produce advanced therapy medicinal
products (ATMPs). We have developed personalized tissue engineered veins (P-TEV) as an …

Anthracyclines, such as doxorubicin, are highly efficient chemotherapeutic agents against a
variety of cancers. However, anthracyclines are also among the most cardiotoxic therapeutic …

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the
market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the …

There is a strong anticipated future for human induced pluripotent stem cell-derived hepatocytes
(hiPS-HEP), but so far, their use has been limited due to insufficient functionality. We …