Clinical relevance of St. John's wort drug interactions revisited

…, HE Meyer zu Schwabedissen - British journal of …, 2020 - Wiley Online Library
The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine
with anti‐depressant effects, interacting with other drugs, altering their bioavailability and …

Regulation of drug transport proteins—From mechanisms to clinical impact: A white paper on behalf of the international transporter consortium

…, CY Li, HE Meyer zu Schwabedissen… - Clinical …, 2022 - Wiley Online Library
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms

HE Meyer zu Schwabedissen, RB Kim - Molecular pharmaceutics, 2009 - ACS Publications
Drug uptake transporters are now increasingly recognized as clinically relevant determinants
of variable drug responsiveness and unexpected drug−drug interactions. Emerging …

Meta-analysis of genome-wide association studies in> 80 000 subjects identifies multiple loci for C-reactive protein levels

…, KH Greiser, O Kuss, HE Meyer zu Schwabedissen… - Circulation, 2011 - Am Heart Assoc
Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

Human skeletal muscle drug transporters determine local exposure and toxicity of statins

…, BL Urquhart, HE Meyer zu Schwabedissen… - Circulation …, 2010 - Am Heart Assoc
Rationale: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, are
important drugs used in the treatment and prevention of cardiovascular disease. Although …

[HTML][HTML] Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

…, SCL Gough, H Meyer zu Schwabedissen… - PLoS …, 2014 - journals.plos.org
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population.
Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of …

[HTML][HTML] Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

…, T De Meyer, HE Meyer zu Schwabedissen… - Nature …, 2018 - nature.com
Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide …

HE Meyer zu Schwabedissen… - American Journal …, 2010 - journals.physiology.org
renal elimination of a number of cationic compounds is thought to be mediated by the
organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the …

Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen …

HE Meyer zu Schwabedissen, RG Tirona, CS Yip… - Cancer research, 2008 - AACR
The ligand-activated nuclear receptor pregnane X receptor (PXR) is known to play a role in
the regulated expression of drug metabolizing enzymes and transporters. Recent studies …

Inverse association between serum free thyroxine levels and hepatic steatosis: results from the Study of Health in Pomerania

…, M Dörr, MM Lerch, HE Meyer zu Schwabedissen… - Thyroid, 2012 - liebertpub.com
Background: Associations between thyroid function and hepatic steatosis defined by enzymatic
and sonographic criteria are largely unknown in the general population. Thus, the aim of …