The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

HK Crewe, MS Lennard, GT Tucker… - British journal of …, 1992 - Wiley Online Library
Inhibition of human cytochrome P4502D6 (CYP2D6)‐catalysed metabolism can lead to
clinically significant alterations in pharmacokinetics. Since there is evidence that the selective …

Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4′-hydroxy andN-desmethyl metabolites and isomerization …

HK Crewe, LM Notley, RM Wunsch, MS Lennard… - Drug metabolism and …, 2002 - ASPET
The cytochrome P450 (P450)-mediated biotransformation of tamoxifen is important in
determining both the clearance of the drug and its conversion to the active metabolite,trans-4-…

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes

HK Crewe, SW Ellis, MS Lennard, GT Tucker - Biochemical pharmacology, 1997 - Elsevier
4-Hydroxylation is an important pathway of tamoxifen metabolism because the product of this
reaction is intrinsically 100 times more potent as an oestrogen receptor antagonist than is …

Abundance of hepatic transporters in Caucasians: a meta-analysis

HJ Burt, AE Riedmaier, MD Harwood, HK Crewe… - Drug metabolism and …, 2016 - ASPET
This study aimed to derive quantitative abundance values for key hepatic transporters suitable
for in vitro–in vivo extrapolation within a physiologically based pharmacokinetic modeling …

Use of quinidine inhibition to define the role of the sparteine/debrisoquine cytochrome P450 in metoprolol oxidation by human liver microsomes.

SV Otton, HK Crewe, MS Lennard, GT Tucker… - … of Pharmacology and …, 1988 - ASPET
The oxidation of the beta adrenoceptor antagonist metoprolol exhibits genetic polymorphism
of the sparteine/debrisoquine (SP/DB) type. The alpha-hydroxylation of metoprolol is …

Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic …

HK Crewe, ZE Barter, K Rowland Yeo… - … & drug disposition, 2011 - Wiley Online Library
The ‘relative activity factor’ (RAF) compares the activity per unit of microsomal protein in
recombinantly expressed cytochrome P450 enzymes (rhCYP) and human liver without …

mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates

MJ Graham, AR Bell, HK Crewe, CL Moorcraft… - Xenobiotica, 2003 - Taylor & Francis
1. Interpretation of novel drug exposure and toxicology data from the dog is tempered by our
limited molecular and functional knowledge of dog cytochromes P450 (CYPs). The aim was …

Determination by liquid chromatography–mass spectrometry of clomiphene isomers in the plasma of patients undergoing treatment for the induction of ovulation

HK Crewe, C Ghobadi, A Gregory… - … of Chromatography B, 2007 - Elsevier
A rapid, sensitive and selective LC–MS method is described for the simultaneous determination
of zuclomiphene and enclomiphene in plasma from patients undergoing treatment with …

The Site of Inversion of R(–)‐Ibuprofen: Studies Using Rat In‐situ Isolated Perfused Intestine/liver Preparations

P Jeffrey, GT Tucker, A Bye, HK Crewe… - Journal of pharmacy …, 1991 - Wiley Online Library
The site of metabolic inversion of R(–)‐ibuprofen to the pharmacologically active S(+)‐enantiomer
has been investigated using an array of in‐situ rat perfused organ preparations …

CYP2D6 is primarily responsible for the metabolism of clomiphene

C Ghobadi, A Gregory, HK Crewe… - Drug metabolism and …, 2008 - Elsevier
Clomiphene is a first line treatment for anovulation, a common cause of infertility. Response
to clomiphene is variable and unpredictable. Tamoxifen is structurally related to clomiphene, …