… Davis is a stockholder and an employee of Centocor, Inc., a division of Johnson & Johnson.
… Davis is a stockholder and an employee of Centocor, Inc., a division of Johnson & Johnson. …

Activation of lymphocytes is a complex, yet finely regulated cascade of events that results in
the expression of cytokine receptors, production and secretion of cytokines and expression …

The authors evaluated interspecies scaling for the prediction of human clearance of 18
therapeutic monoclonal antibodies (mAbs). Human and monkey/chimpanzee data of 14 mAbs …

Background & Aims We analyzed data collected during the Active Ulcerative Colitis Trials (ACT-1
and ACT-2) to assess relationships between serum concentrations of infliximab and …

Purpose Infliximab, a monoclonal antibody, is approved for the treatment of inflammatory
diseases at doses that depend on the patient disease population. It was the aim of this study to …

BACKGROUND: Infliximab is a chimeric monoclonal antibody against TNFα. The pharmacokinetic
(PK) properties of infliximab have been studied in several adult patient populations, …

Objectives Infliximab, an IgG1 monoclonal antibody (mab), has large inter-individual serum
concentration variability. The objective was to determine the extent of the association of …

Golimumab is a fully human antitumor necrosis factor alpha (TNF‐α) monoclonal antibody
that is being developed for intravenous and subcutaneous administration. To assess the …

Background & Aims Ustekinumab is a monoclonal antibody that binds with high affinity to the
p40 subunit of human interleukin 12 (IL12 and IL23) that has been approved for treatment …

The murine monoclonal antibody OC125 reacts with an antigenic determinant (CA 125) found
on a high-molecular-weight glycoprotein complex present in the serum of greater than 80…