We sought to develop 11 C-labeled ligands for sensitive imaging of brain peripheral
benzodiazepine receptors (PBR) in vivo. Two aryloxyanilides with high affinity for PBR were …

Objective: 1 H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI)
and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia …

18 F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane ( 18 F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …

OBJECTIVE: An extra portion of chromosome 21 in Down’s syndrome leads to a dementia
in later life that is phenotypically similar to Alzheimer’s disease. Down’s syndrome therefore …

Phospholipid composition (mol %) and levels (nmol/mg protein) were determined in postmortem
frontal cortical and cerebellar gray matter from older Down Syndrome (DS) patients (…

This study evaluated 18 F-labeled IMPY [6-iodo-2-(4‘-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine]
derivatives as agents for imaging β-amyloid plaque with positron emission …

Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated
microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for …

Unidirectional blood-brain barrier transfer of the lipophilic anticancer agents vincristine and
vinblastine was studied in anesthetized rats, using an isolated, in situ brain perfusion …

Radiotracers labeled with carbon-11 (t 1/2 = 20.4 min) are widely used with positron emission
tomography for biomedical research. Radiotracers must be produced for positron emission …

Until recently, brain phospholipid metabolism was thought to consume only 2% of the ATP
consumed by the mammalian brain as a whole. In this paper, however, we calculate that 1.4% …