User profiles for H. U. Shetty
H. Umesha ShettyChemist, National Institutes of Health Verified email at mail.nih.gov Cited by 2336 |
Synthesis and Evaluation in Monkey of Two Sensitive 11C-Labeled Aryloxyanilide Ligands for Imaging Brain Peripheral Benzodiazepine Receptors In Vivo
…, M Imaizumi, JP Gourley, HU Shetty… - Journal of medicinal …, 2008 - ACS Publications
We sought to develop 11 C-labeled ligands for sensitive imaging of brain peripheral
benzodiazepine receptors (PBR) in vivo. Two aryloxyanilides with high affinity for PBR were …
benzodiazepine receptors (PBR) in vivo. Two aryloxyanilides with high affinity for PBR were …
Brain metabolite concentration and dementia severity in Alzheimer's disease: A 1H MRS study
W Huang, GE Alexander, L Chang, HU Shetty… - Neurology, 2001 - AAN Enterprises
Objective: 1 H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI)
and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia …
and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia …
PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements
18 F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane ( 18 F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …
High Brain myo-Inositol Levels in the Predementia Phase of Alzheimer's Disease in Adults With Down's Syndrome: A 1H MRS Study
…, GE Alexander, EM Daly, HU Shetty… - American Journal of …, 1999 - Am Psychiatric Assoc
OBJECTIVE: An extra portion of chromosome 21 in Down’s syndrome leads to a dementia
in later life that is phenotypically similar to Alzheimer’s disease. Down’s syndrome therefore …
in later life that is phenotypically similar to Alzheimer’s disease. Down’s syndrome therefore …
Phospholipid composition and levels are altered in Down syndrome brain
EJ Murphy, MB Schapiro, SI Rapoport, HU Shetty - Brain research, 2000 - Elsevier
Phospholipid composition (mol %) and levels (nmol/mg protein) were determined in postmortem
frontal cortical and cerebellar gray matter from older Down Syndrome (DS) patients (…
frontal cortical and cerebellar gray matter from older Down Syndrome (DS) patients (…
Synthesis and Evaluation of Two 18F-Labeled 6-Iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine Derivatives as Prospective Radioligands for β …
…, SS Zoghbi, K Modell, E Briard, HU Shetty… - Journal of medicinal …, 2004 - ACS Publications
This study evaluated 18 F-labeled IMPY [6-iodo-2-(4‘-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine]
derivatives as agents for imaging β-amyloid plaque with positron emission …
derivatives as agents for imaging β-amyloid plaque with positron emission …
Single-Step High-Yield Radiosynthesis and Evaluation of a Sensitive 18F-Labeled Ligand for Imaging Brain Peripheral Benzodiazepine Receptors with PET
…, M Imaizumi, JP Gourley, HU Shetty… - Journal of medicinal …, 2009 - ACS Publications
Elevated levels of peripheral benzodiazepine receptors (PBR) are associated with activated
microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for …
microglia in their response to inflammation. Hence, PBR imaging in vivo is valuable for …
Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat
Unidirectional blood-brain barrier transfer of the lipophilic anticancer agents vincristine and
vinblastine was studied in anesthetized rats, using an isolated, in situ brain perfusion …
vinblastine was studied in anesthetized rats, using an isolated, in situ brain perfusion …
Translation of 11C-labeled tracer synthesis to a CGMP environment as exemplified by [11C]ER176 for PET imaging of human TSPO
J Hong, S Telu, Y Zhang, WH Miller, HU Shetty… - Nature …, 2021 - nature.com
Radiotracers labeled with carbon-11 (t 1/2 = 20.4 min) are widely used with positron emission
tomography for biomedical research. Radiotracers must be produced for positron emission …
tomography for biomedical research. Radiotracers must be produced for positron emission …
Energy consumption by phospholipid metabolism in mammalian brain
AD Purdon, TA Rosenberger, HU Shetty… - Neurochemical …, 2002 - Springer
Until recently, brain phospholipid metabolism was thought to consume only 2% of the ATP
consumed by the mammalian brain as a whole. In this paper, however, we calculate that 1.4% …
consumed by the mammalian brain as a whole. In this paper, however, we calculate that 1.4% …