Introduction: Oxysterols are implicated in various cellular processes. Among their target
proteins, liver X receptors (LXRs) α and β modulate the cell cycle in a large range of cancer cell …

The ABCC6 gene encodes an organic anion transporter protein, ABCC6/MRP6. Mutations
in the gene cause a rare, recessive genetic disease, pseudoxanthoma elasticum, while the …

Oxysterols derive from cholesterol oxidation. They display various biological activities such
as regulating cholesterol, fatty acid and glucose homeostasis as well as cell survival/…

Multiple myeloma (MM) account for approximately 10% of hematological malignancies and
is the second most common hematological disorder. Kinases inhibitors are widely used and …

LXR (Liver X Receptors) act as “sensor” proteins that regulate cholesterol uptake, storage,
and efflux. LXR signaling is known to influence proliferation of different cell types including …

Cholesterol is a fundamental molecule for life. Located in the cell membrane, this sterol
participates to the cell signaling of growth factors. Inside the cell it can be converted in hormones …

… Treatments were carried out 24 h after transfection and for 24 h. Co-transfections of reporter
constructs and plasmids carrying cDNA for selected transcription factors were performed …

Liver failure remains the leading cause of post‐operative mortality after hepatectomy. This
study investigated the effect of treatment with allogenic mesenchymal stem cells (MSCs) on …

… Washed again 3 x 5 minutes with PBS-0.01% Tween, incubated with DAPI (20 μg/ml) in
H 2 O for 5 minutes and washed 3 times with H 2 O. Slides were air dried and mounted with …

Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to
understand the molecular processes that drive MM biology. Epigenetic modifications are …