ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane domains. …

Background: The last 15 years have marked an expansion in our understanding of how ABC
transporters modulate the pharmacokinetic properties of drugs. Assays based on different …

Ivermectin is a potent antiparasitic drug from macrocyclic lactone (ML) family, which interacts
with the ABC multidrug transporter P-glycoprotein (Pgp). We studied the interactions of …

The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested
to play an important role in cellular lipid/sterol regulation but no experimental data for their …

… vanadate-sensitive ATPase activity of human cell membranes expressing similar amounts
of ABCG2 can be stimulated by substrate of the transporter (H. Glavinas, E. Kis,Á. Pál, R. …

The exporter ABCC2 (cMOAT, MRP2) is a membrane-bound protein on the apical side of
enterocytes and hepatic biliary vessels that transports leukotriene C 4 , glutathione, some …

… We measured the vesicular transport of [ 3 H]methotrexate at pH 5.5 and 7.0 using our
MXR-M vesicles at different methotrexate concentrations (up to 3 mM). The rate of transport at …

Transporter mediated drug–drug interactions (tDDI) mediated by ABCB1 have been shown
to be clinically relevant. Hence, the assessment of the ABCB1 tDDI potential early in the drug …

… carbonate-bicarbonate buffer (0.5 ml, pH = 9.03), was allowed to react with 7.5 mg (20 µmol)
of fluorescein isothiocyanate isomer I (Sigma) under stirring for 24 h at room temperature in …

We tested the hypothesis whether data on ABCB1 ATPase activity and passive permeability
can be used in combination to identify ABCB1 substrates and inhibitors. We determined …