Publisher Summary The compound ebselen is considered capable of contributing to the
antioxidant defense in tissues. Many of the biological properties of ebselen were explainable on …

… h, K56-acetylated histone H3 is present in the chromatin fraction. Spheroplasts prepared
from wild-type cells in exponential phase were lysed in buffer containing 1% Triton X-100 (TX-…

… After 1 h at 0C with gentle agitation, the suspension was centrifuged at 25,000 rpm for 1 h
in a rotor (Type 40; Beckman Instruments, Fullerton, CA). The pellet was resuspended and …

… The modified YAC constructs have 1.1 kb of h'TEL sequences flanked by 0.3 kb ofyeast
telomere sequences at the end of each arm. This h'TEL sequence has been shown to form …

The centromere is an essential functional domain responsible for the correct inheritance of
eukaryotic chromosomes during cell division. Eukaryotic centromeres include the highly …

Calpains (calcium-dependent cytoplasmic cysteine proteinases) are implicated in processes
such as cytoskeleton remodeling and signal transduction. The 2.3-Å crystal structure of full-…

This is a clinical safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) study
of a single ascending dose (SAD) and a multiple ascending dose (MAD) of the oral direct …

A rapid, multiresidue procedure utilizing the minimal cleanup necessary for gas-liquid
chromatographic (GLC) analysis is presented. The samples are extracted with acetone and …

… Masumoto and colleagues [49] discovered that in HT1080 cells the level of H3K9me3 on …
measles virus envelop proteins, H and F, in the recipient cells has been described [79]. The …

Kinetochores assemble on distinct ‘centrochromatin’ containing the histone H3 variant CENP‐A
and interspersed nucleosomes dimethylated on H3K4 (H3K4me2). Little is known about …