[HTML][HTML] Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

…, J Zhao, X Hong, Y Zhang, F Zhou, HB Luo - … Pharmaceutica Sinica B, 2020 - Elsevier
… Jincun Zhao, Xuechuan Hong, Yuxia Zhang, Fuling Zhou, and Hai-Bin Luo co-designed the
… Zhanghua Chen, Yuxia Zhang, and Hai-Bin Luo analyzed data and generated the tables …

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

…, J Cui, CG Zhan, X Wang, HB Luo - Proceedings of the …, 2020 - National Acad Sciences
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has become a global crisis. There is no therapeutic treatment specific for COVID-19…

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease

C Lu, Y Guo, J Yan, Z Luo, HB Luo, M Yan… - Journal of Medicinal …, 2013 - ACS Publications
A series of multitarget-directed resveratrol derivatives was designed and synthesized for the
treatment of Alzheimer’s disease (AD). In vitro studies indicated that most of the target …

[HTML][HTML] Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer

…, ZY Wang, SL Mo, TY Loo, DM Wang, HB Luo… - Breast cancer research …, 2012 - Springer
Anti-angiogenesis targeting VEGFR-2 has been considered as an important strategy for
cancer therapy. Ellagic acid is a naturally existing polyphenol widely found in fruits and …

Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen

Z Luo, J Sheng, Y Sun, C Lu, J Yan, A Liu… - Journal of medicinal …, 2013 - ACS Publications
A novel series of compounds obtained by fusing the cholinesterase inhibitor donepezil and
the antioxidant ebselen were designed as multi-target-directed ligands against Alzheimer’s …

ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism

…, F Bai, J Cui, AM Lew, J Zhao, Y Zhang, HB Luo… - MedRxiv, 2020 - medrxiv.org
Respiratory disease caused by the 2019 novel coronavirus (2019-nCoV) pneumonia first
emerged in Wuhan, Hubei Province, China, in December 2019 and spread rapidly to other …

[HTML][HTML] Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut …

…, YP Wang, LB Pan, H Yu, CY He, HB Luo… - … Pharmaceutica Sinica B, 2022 - Elsevier
Morinda officinalis oligosaccharides (MOO) are an oral drug approved in China for the
treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant …

Novel phosphodiesterase inhibitors for cognitive improvement in Alzheimer's Disease: Miniperspective

…, Z Li, YY Huang, D Wu, HB Luo - Journal of medicinal …, 2018 - ACS Publications
Alzheimer’s disease (AD) is one of the greatest public health challenges. Phosphodiesterases
(PDEs) are a superenzyme family responsible for the hydrolysis of two second …

Selaginpulvilins A–D, New Phosphodiesterase-4 Inhibitors with an Unprecedented Skeleton from Selaginella pulvinata

X Liu, HB Luo, YY Huang, JM Bao, GH Tang… - Organic …, 2014 - ACS Publications
Selaginpulvilins A–D (1–4), four new phenols with an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene
skeleton, together with four known selaginellins (5–8) were isolated …

Single-particle enzyme activity assay with spectral-resolved dark-field optical microscopy

F Wang, Y Li, Y Han, Z Ye, L Wei, HB Luo… - Analytical …, 2019 - ACS Publications
In a clinical assay, enzymes are essential biomarkers for human disease diagnosis. In this
work, a spectral-resolved single-particle detection (SPD) method is introduced to quantify …