The purpose of this study was to thoroughly characterize the efflux transporters involved in
the intestinal permeability of the oral microtubule polymerization inhibitor colchicine and to …

The aim of this study was to elucidate the intestinal epithelial cell efflux transport processes
that are involved in the intestinal transport of the H 2 receptor antagonist nizatidine. The …

Human cytomegalovirus (HCMV) is a prevalent virus that infects up to 90% of the population.
The goal of this research is to determine if small molecular prodrug substrates can be …

The fluorophosphonate (FP) moiety attached to a biotin tag is a prototype chemical probe
used to quantitatively analyze and enrich active serine hydrolases in complex proteomes in an …

Human apical sodium-dependent bile acid transporter (hASBT, SLC10A2) is responsible for
intestinal reabsorption of bile acids and plays a key role in cholesterol homeostasis. We …

The prodrug strategy has been frequently employed as a chemical approach for overcoming
the disadvantages of existing parent drugs. In this report, we synthesized four monoester …

Prodrug approaches have been widely used to overcome pharmaceutical and pharmacokinetics
barriers. However, knowledge about site (s) of prodrug activation is frequently limited. …

… I have been very lucky to go through the experience of graduate school "side by side" with
my beloved husband, Hairat Sabit. Knowing each other's daily struggles and challenges …

Modifications of the surface properties of liposomal drug carriers, such as coating with
therapeutic or targeting proteins, greatly impact their delivery performance. Many of the currently-…

Valacyclovir hydrolase (VACVase) is a prod rug-activating enzyme that catalyzes the hydrolytic
activation of the antiviral prodrug valacyclovir to L-valine and acyclovir, and is a target for …