Angptl3 regulates lipid metabolism in mice
R Koishi, Y Ando, M Ono, M Shimamura, H Yasumo… - Nature …, 2002 - nature.com
The KK obese mouse is moderately obese and has abnormally high levels of plasma insulin
(hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/…
(hyperinsulinemia), glucose (hyperglycemia) and lipids (hyperlipidemia). In one strain (KK/…
Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase
M Shimamura, M Matsuda, H Yasumo… - … , and vascular biology, 2007 - Am Heart Assoc
Objectives— A low level of high-density lipoprotein (HDL) in plasma has been recognized
as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. …
as an aspect of metabolic syndrome and as a crucial risk factor of cardiovascular events. …
A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus
…, M Shimizu, M Sugawara, H Yasumo… - Clinical …, 2003 - Wiley Online Library
Background and objective Troglitazone is a 2,4‐thiazolidinedione antidiabetic agent with
insulin‐sensitizing activities. This agent had been used efficiently in a large number of patients …
insulin‐sensitizing activities. This agent had been used efficiently in a large number of patients …
[HTML][HTML] Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor
…, N Takei, N Terasaka, Y Ando, H Yasumo… - Journal of Biological …, 2003 - ASBMB
The KK/San obese and diabetic mouse, a mutant strain from KK obese mice, exhibits significantly
low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in …
low plasma triglyceride levels. In KK/San mice, genetic analysis identified a mutation in …
Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor
…, M Matsuda, Y Ando, R Koishi, H Yasumo… - Biochemical and …, 2004 - Elsevier
We reported previously that angiopoietin-like protein3 (ANGPTL3), a liver-specific secretory
factor, increased plasma triglyceride (TG) via inhibition of lipoprotein lipase and free fatty …
factor, increased plasma triglyceride (TG) via inhibition of lipoprotein lipase and free fatty …
Peroxisome assembly factor–2, a putative ATPase cloned by functional complementation on a peroxisome–deficient mammalian cell mutant
…, T Orii, Y Fujiki, F Sakai, A Bogaki, H Yasumo… - Nature …, 1995 - nature.com
Rat peroxisome assembly factor–2 (PAF–2) cDNA was isolated by functional complementation
of peroxisome deficiency of a mutant CHO cell line, ZP92, using transient transfection …
of peroxisome deficiency of a mutant CHO cell line, ZP92, using transient transfection …
Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors
H Yasumo, N Masuda, T Furusawa… - … et Biophysica Acta (BBA …, 2000 - Elsevier
A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid
screening, as an interaction partner of peroxisome proliferator-activated receptor α as …
screening, as an interaction partner of peroxisome proliferator-activated receptor α as …
Improvement of single nucleotide polymorphism genotyping by allele-specific PCR using primers modified with an ENA residue
M Koizumi, K Morita, M Takagi, H Yasumo… - Analytical biochemistry, 2005 - Elsevier
When we placed an ENA residue into primers at the 3′ end, or the n-1, n-2, or n-3 position,
which included a single nucleotide polymorphism (SNP) site at the 3′ end, only primers …
which included a single nucleotide polymorphism (SNP) site at the 3′ end, only primers …
An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors
N Masuda, H Yasumo, T Tamura, N Hashiguchi… - … et Biophysica Acta (BBA …, 1997 - Elsevier
The yeast two-hybrid screening was applied to cloning cDNAs of proteins that interact with
peroxisome proliferator-activated receptor α (PPARα). We obtained from a rat liver cDNA …
peroxisome proliferator-activated receptor α (PPARα). We obtained from a rat liver cDNA …
Characterization of phenotypes in Gstm1-null mice by cytosolic and in vivo metabolic studies using 1, 2-dichloro-4-nitrobenzene
…, Y Shibaya, H Miida, Y Ando, H Yasumo… - Drug metabolism and …, 2006 - ASPET
Glutathione S-transferase Mu 1 (GSTM1) has been regarded as one of the key enzymes
involved in phase II reactions in the liver, because of its high expression level. In this study, we …
involved in phase II reactions in the liver, because of its high expression level. In this study, we …