User profiles for Houfu Liu

Houfu Liu

GlaxoSmithKline
Verified email at gsk.com
Cited by 1596

Prediction of brain: blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

H Liu, K Dong, W Zhang, SG Summerfield… - Drug discovery today, 2018 - Elsevier
Highlights • Increase in K p, uu, br/CL int translates into higher drug brain unbound
exposure • The performance of current in silico K p, uu, br models is moderate • A deep …

Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats

H Liu, J Yang, F Du, X Gao, X Ma, Y Huang, F Xu… - Drug Metabolism and …, 2009 - ASPET
Panax notoginseng (Sanqi) is a cardiovascular herb containing ginsenosides that are
believed to be responsible for the therapeutic effects of Sanqi. The aim of this study was to …

Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2–Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of …

H Liu, N Yu, S Lu, S Ito, X Zhang, B Prasad, E He… - Drug Metabolism and …, 2015 - ASPET
Organic anion-transporting polypeptide (OATP) 1A2 has the potential to be a target for
central nervous system drug delivery due to its luminal localization at the human blood-brain …

Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier

Z Cheng, H Liu, N Yu, F Wang, G An, Y Xu, Q Liu… - Xenobiotica, 2012 - Taylor & Francis
OATP1A2 is expressed in the luminal membrane of human blood-brain barrier (BBB). The
human tissue with the highest OATP1A2 mRNA expression is the brain. We have established …

Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System

YY Zhang, H Liu, SG Summerfield… - Molecular …, 2016 - ACS Publications
Estimation of uptake across the blood–brain barrier (BBB) is key to designing central nervous
system (CNS) therapeutics. In silico approaches ranging from physicochemical rules to …

Drug distribution into peripheral nerve

H Liu, Y Chen, L Huang, X Sun, T Fu, S Wu… - … of Pharmacology and …, 2018 - ASPET
Little is known about the impact of the blood–nerve barrier (BNB) on drug distribution into
peripheral nerves. In this study, we examined the peripheral nerve penetration in rats of 11 …

[HTML][HTML] Prognostic value of thyroid hormones in acute ischemic stroke–a meta analysis

X Jiang, H Xing, J Wu, R Du, H Liu, J Chen, J Wang… - Scientific Reports, 2017 - nature.com
Previous studies on the association between thyroid hormones and prognosis of acute
ischemic stroke (AIS) reported conflicting results. We conducted a meta-analysis to assess the …

Comparative metabolic capabilities and inhibitory profiles of CYP2D6. 1, CYP2D6. 10, and CYP2D6. 17

H Shen, MM He, H Liu, SA Wrighton, L Wang… - Drug Metabolism and …, 2007 - ASPET
Polymorphisms in the cytochrome P450 2D6 (CYP2D6) gene are a major cause of
pharmacokinetic variability in human. Although the poor metabolizer phenotype is known to be …

Role of hepatic drug transporters in drug development

H Liu, J Sahi - The Journal of Clinical Pharmacology, 2016 - Wiley Online Library
Hepatic drug transporters can play an important role in pharmacokinetics and the disposition
of therapeutic drugs and endogenous substances. Altered function of hepatic drug …

Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis-and Alzheimer's disease-related animal models …

Z Cheng, J Zhang, H Liu, Y Li, Y Zhao, E Yang - Drug metabolism and …, 2010 - ASPET
Therapy for central nervous system (CNS) diseases requires drugs that can cross the blood-brain
barrier (BBB). BBB disruption has been reported in patients with multiple sclerosis (MS…