User profiles for Hsia-lien Lin
 | Hsia-lien LinUniversity of Michigan Verified email at umich.edu Cited by 5949 |
Mechanism-based inactivation of cytochrome P450 3A4 by 17α-ethynylestradiol: evidence for heme destruction and covalent binding to protein
H Lin, UM Kent, PF Hollenberg - Journal of Pharmacology and Experimental …, 2002 - ASPET
17α-Ethynylestradiol (EE), a major constituent of many oral contraceptives, inactivated the
testosterone 6β-hydroxylation activity of purified P450 3A4 reconstituted with phospholipid …
testosterone 6β-hydroxylation activity of purified P450 3A4 reconstituted with phospholipid …
The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to …
H Lin, UM Kent, PF Hollenberg - Journal of Pharmacology and Experimental …, 2005 - ASPET
Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of
cytochromes P450 (P450) 2B6 and 3A5 in the reconstituted system. The inactivation of both …
cytochromes P450 (P450) 2B6 and 3A5 in the reconstituted system. The inactivation of both …
Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1
ES Roberts, H Lin, JR Crowley… - Chemical research in …, 1998 - ACS Publications
The addition of peroxynitrite to purified cytochrome P450 2B1 resulted in a concentration-dependent
loss of the NADPH- and reductase-supported or tert-butylhydroperoxide-supported …
loss of the NADPH- and reductase-supported or tert-butylhydroperoxide-supported …
Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect
Previous studies have demonstrated that bergamottin (BG), a component of grapefruit juice,
is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-…
is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-…
N-Nitrosodimethylamine-Mediated Formation of Oxidized and Methylated DNA Bases in a Cytochrome P450 2E1 Expressing Cell Line
H Lin, PF Hollenberg - Chemical research in toxicology, 2001 - ACS Publications
The metabolic activation of N-nitrosodimethylamine (NDMA) to reactive metabolites is a
critical step for the expression of its toxic and carcinogenic potential. We have previously …
critical step for the expression of its toxic and carcinogenic potential. We have previously …
Mechanism-based inactivation of human CYP2E1 by diethyldithocarbamate
Although the ability of disulfiram to inactivate CYP2E1 has been known for more than 20
years, the mechanism has not yet been elucidated. A metabolite of disulfiram, …
years, the mechanism has not yet been elucidated. A metabolite of disulfiram, …
Metabolism of bergamottin by cytochromes P450 2B6 and 3A5
Cytochromes P450 (P450) 2B6 and 3A5 are inactivated by bergamottin (BG). P450 2B6
metabolized BG primarily to M3 and M4 and one minor metabolite (M1). The metabolites were …
metabolized BG primarily to M3 and M4 and one minor metabolite (M1). The metabolites were …
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation
Y Morishima, HM Peng, H Lin, PF Hollenberg… - Biochemistry, 2005 - ACS Publications
Alcohol-inducible cytochrome P450 2E1 (CYP2E1) has the most rapid turnover of any member
of this large family of membrane-bound oxygenases, and its degradation rate is altered …
of this large family of membrane-bound oxygenases, and its degradation rate is altered …
Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert-Butylphenylacetylene: Insight into Partial …
A combined structural and computational analysis of rabbit cytochrome P450 2B4 covalently
bound to the mechanism-based inactivator tert-butylphenylacetylene (tBPA) has yielded …
bound to the mechanism-based inactivator tert-butylphenylacetylene (tBPA) has yielded …
Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite
We have previously reported that cytochrome P450 2B1 was inactivated by peroxynitrite
and that the decrease in the catalytic activity correlated with an increase in the nitration of …
and that the decrease in the catalytic activity correlated with an increase in the nitration of …