Resveratrol (RES) has been shown to possess many pharmacological activities including
protective effect against liver damage induced by hepatotoxins. In the present study, the hepato…

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses hepato…

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and …

Schisandra sphenanthera is widely used as a tonic and restorative in many countries to
enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an ethanol …

We previously reported that the ethanol extract of Schisandra sphenanthera [Wuzhi (WZ)
tablet] significantly protects against acetaminophen-induced hepatoxicity. However, whether …

Acetaminophen (APAP) hepatotoxicity is the most common cause of drug-induced liver
injury and N-acetylcysteine (NAC) is the primary antidote of APAP poisoning. Wuzhi tablet (WZ), …

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury. Compensatory
liver regeneration is crucial for the final outcome of toxicant-induced injury. However, …

Aim: The nuclear factor erythroid 2-related factor 2 (NRF2) acts through the antioxidant
response element (ARE) to regulate the expression of many detoxifying and antioxidant genes …

The pregnane X receptor (PXR) has been well-established as a critical mediator in regulating
important drug metabolizing enzymes and transporter proteins, including cytochrome …

We previously reported the ethanol extract of Schisandra sphenanthera (Wuzhi tablet, WZ)
significantly protects against acetaminophen-induced hepatoxicity. However, whether it …