In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy
as part of their treatment, which is one of the most cost-effective cancer treatments. …

In recent years the idea of using gene therapy as a modality in the treatment of diseases other
than genetically inherited, monogenic disorders has taken root. This is particularly obvious …

There is a growing appreciation of the potential value of combining novel molecularly-targeted
drugs with radiotherapy or chemoradiotherapy. Such approaches have the potential to …

Recent studies of tissue culture cells have defined a widespread system of oxygen-regulated
gene expression based on the activation of a heterodimeric transcription factor termed …

Animal experiments remain essential to understand the fundamental mechanisms underpinning
malignancy and to discover improved methods to prevent, diagnose and treat cancer. …

Radiotherapy is a major part in the treatment of most common cancers, but many patients
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …

There is increasing evidence that hypoxia-regulated gene expression influences tumor
aggressiveness, contributing to the poorer outcome of patients with hypoxic tumors. The role of …

… IJ Stratford and KJ Williams are conducting research sponsored by Agouron Pfizer. … Williams
KJ, Telfer BA, Stratford IJ, Wedge SR. ZD1839 (‘Iressa’), a specific oral epidermal growth …

… Robinson, KJ Williams, and IJ Stratford, personal communication). Oxygen deprivation … ,
Sheridan MR, van der Kogel AJ, Harris AL, and Stratford IJ. 2002. A protective role for HIF-1 in …

Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as celts in
this environment often survive radiation and chemotherapy. In this report we describe how …