Design of liposomes as drug delivery system for therapeutic applications

D Guimarães, A Cavaco-Paulo, E Nogueira - International journal of …, 2021 - Elsevier
Liposomes are spherical vesicles consisting of one or more concentric phospholipid bilayers
enclosing an aqueous core. Being both nontoxic and biodegradable, liposomes represent …

Metabolic regulation is important for spermatogenesis

…, MG Alves, S Socorro, AI Duarte, JE Cavaco… - Nature Reviews …, 2012 - nature.com
Male factor infertility is increasing in developed countries, and several factors linked to
lifestyle have been shown to negatively affect spermatogenesis. Sertoli cells are pivotal to …

[HTML][HTML] A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

L Cantas, SQ Shah, LM Cavaco, F Walsh… - Frontiers in …, 2013 - frontiersin.org
The discovery and introduction of antimicrobial agents to clinical medicine was one of the
greatest medical triumphs of the 20th century that revolutionized the treatment of bacterial …

[HTML][HTML] The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung …

…, M Okumura, E Blackstone, FA Cavaco… - Journal of Thoracic …, 2016 - Elsevier
The IASLC Staging and Prognostic Factors Committee has collected a new database of
94,708 cases donated from 35 sources in 16 countries around the globe. This has now been …

Decolorization and Detoxification of Textile Dyes with a Laccase from Trametes hirsuta

…, S Costa, KH Robra, A Cavaco-Paulo… - Applied and …, 2000 - Am Soc Microbiol
Trametes hirsuta and a purified laccase from this organism were able to degrade triarylmethane,
indigoid, azo, and anthraquinonic dyes. Initial decolorization velocities depended on …

HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome

…, B Robinson, RJ Zarbo, BM Cavaco… - Nature …, 2002 - nature.com
We report here the identification of a gene associated with the hyperparathyroidism–jaw
tumor (HPT–JT) syndrome. A single locus associated with HPT–JT (HRPT2) was previously …

qnrD, a Novel Gene Conferring Transferable Quinolone Resistance in Salmonella enterica Serovar Kentucky and Bovismorbificans Strains of Human Origin

LM Cavaco, H Hasman, S Xia… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
In a previous study, four Salmonella isolates from humans in the Henan province of China
showed reduced susceptibility to ciprofloxacin (MIC, 0.125 to 0.25 μg/ml) but were susceptible …

TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas

…, C Lobo, MJ Martins, M Moura, B Cavaco… - The Journal of …, 2014 - academic.oup.com
Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived
thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. …

PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens

…, R Allesøe, KG Joensen, LM Cavaco… - Journal of …, 2017 - academic.oup.com
Background Antibiotic resistance is a major health problem, as drugs that were once highly
effective no longer cure bacterial infections. WGS has previously been shown to be an …

Biodegradable materials based on silk fibroin and keratin

A Vasconcelos, G Freddi, A Cavaco-Paulo - Biomacromolecules, 2008 - ACS Publications
Wool and silk were dissolved and used for the preparation of blended films. Two systems
are proposed: (1) blend films of silk fibroin and keratin aqueous solutions and (2) silk fibroin …