User profiles for Imhoi Koo
Imhoi KooHuck Institutes of Life Sciences Verified email at psu.edu Cited by 1747 |
Current challenges and recent developments in mass spectrometry–based metabolomics
High-resolution mass spectrometry (MS) has advanced the study of metabolism in living
systems by allowing many metabolites to be measured in a single experiment. Although …
systems by allowing many metabolites to be measured in a single experiment. Although …
Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
Commensal microbiota-dependent tryptophan catabolism within the gastrointestinal tract is
known to exert profound effects upon host physiology, including the maintenance of …
known to exert profound effects upon host physiology, including the maintenance of …
The microbiome modulating activity of bile acids
Bile acids are potent antibacterial compounds and play an important role in shaping the
microbial ecology of the gut. Here, we combined flow cytometry, growth rate measurements (OD …
microbial ecology of the gut. Here, we combined flow cytometry, growth rate measurements (OD …
The pretreatment gut microbiome is associated with lack of response to methotrexate in new‐onset rheumatoid arthritis
…, A Flor‐Duro, M Alexander, I Koo… - Arthritis & …, 2021 - Wiley Online Library
Objective Although oral methotrexate (MTX) remains the anchor drug for rheumatoid arthritis
(RA), up to 50% of patients do not achieve a clinically adequate outcome. In addition, there …
(RA), up to 50% of patients do not achieve a clinically adequate outcome. In addition, there …
[HTML][HTML] AHR is a master regulator of diverse pathways in endogenous metabolism
JC Granados, K Falah, I Koo, EW Morgan… - Scientific reports, 2022 - nature.com
The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification,
development, immune response, chronic kidney disease and other syndromes. It regulates the …
development, immune response, chronic kidney disease and other syndromes. It regulates the …
Comparative analysis of mass spectral matching-based compound identification in gas chromatography–mass spectrometry
Compound identification in gas chromatography–mass spectrometry (GC–MS) is usually
achieved by matching query spectra to spectra present in a reference library. Although several …
achieved by matching query spectra to spectra present in a reference library. Although several …
Berberine directly affects the gut microbiota to promote intestinal farnesoid X receptor activation
Intestinal bacteria play an important role in bile acid metabolism and in the regulation of
multiple host metabolic pathways (eg, lipid and glucose homeostasis) through modulation of …
multiple host metabolic pathways (eg, lipid and glucose homeostasis) through modulation of …
Wavelet-and Fourier-transform-based spectrum similarity approaches to compound identification in gas chromatography/mass spectrometry
The high-throughput gas chromatography/mass spectrometry (GC/MS) technology offers a
powerful means of analyzing a large number of chemical and biological samples. One of the …
powerful means of analyzing a large number of chemical and biological samples. One of the …
Compound identification in GC-MS by simultaneously evaluating the mass spectrum and retention index
We report a compound identification method (SimMR), which simultaneously evaluates the
mass spectrum similarity and the retention index distance using an empirical mixture score …
mass spectrum similarity and the retention index distance using an empirical mixture score …
MetSign: a computational platform for high-resolution mass spectrometry-based metabolomics
Data analysis in metabolomics is currently a major challenge, particularly when large sample
sets are analyzed. Herein, we present a novel computational platform entitled MetSign for …
sets are analyzed. Herein, we present a novel computational platform entitled MetSign for …