Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes
…, M Antonsson, AK Naudot, I Skånberg… - Drug Metabolism and …, 2000 - ASPET
This study demonstrates the stereoselective metabolism of the optical isomers of omeprazole
in human liver microsomes. The intrinsic clearance (CL int ) of the formation of the hydroxy …
in human liver microsomes. The intrinsic clearance (CL int ) of the formation of the hydroxy …
Inhibition of gastric acid secretion by omeprazole in the dog and rat
…, ULF Junggren, L Olbe, SE Sjöstrand, I Skånberg… - Gastroenterology, 1983 - Elsevier
The gastric antisecretory properties of omeprazole, a new potent substituted benzimidazole,
have been evaluated in dogs and rats. Omeprazole was compared with another …
have been evaluated in dogs and rats. Omeprazole was compared with another …
Stereoselective metabolism by human liver CYP enzymes of a substituted benzimidazole
…, TB Andersson, ULF Bredberg, I Skånberg… - Drug metabolism and …, 2000 - ASPET
H 259/31 is a substituted benzimidazole developed as a structural analog of omeprazole.
Metabolites of H 259/31 formed in human liver microsomes were identified by using the …
Metabolites of H 259/31 formed in human liver microsomes were identified by using the …
Pharmacokinetics of [14C]Omeprazole in Patients with Liver Cirrhosis
…, R Olsson, CG Regårdh, I Skånberg - Clinical pharmacokinetics, 1993 - Springer
The pharmacokinetics of omeprazole and its metabolites following single doses were studied
in 8 patients with liver cirrhosis. Each patient participated in 2 experiments in which [ 14 C]…
in 8 patients with liver cirrhosis. Each patient participated in 2 experiments in which [ 14 C]…
Pharmacokinetics of [14C] omeprazole in patients with impaired renal function
…, R Larsson, CG Regårdh, I Skånberg… - Clinical …, 1986 - Wiley Online Library
Pharmacokinetics of [ 14 C] omeprazole and its metabolites were studied after single
intravenous and oral doses of 20 and 40 mg, respectively, to 12 patients with chronic renal …
intravenous and oral doses of 20 and 40 mg, respectively, to 12 patients with chronic renal …
Pharmacokinetic study of omeprazole in elderly healthy volunteers
…, P Lundborg, CG Regårdh, E Sixt, I Skånberg - Clinical …, 1992 - Springer
The pharmacokinetics of omeprazole and its metabolites were studied in 8 healthy elderly
volunteers using [ 14 C]omeprazole. In another 6 healthy elderly volunteers, the …
volunteers using [ 14 C]omeprazole. In another 6 healthy elderly volunteers, the …
[PDF][PDF] Chemical reactions of omeprazole and omeprazole analogues. I. A survey of the chemical transformations of omeprazole and its analogues
J Hoffmann, S Johansson, S Larsson… - Acta Chemica …, 1989 - actachemscand.org
The chemical reactions of the H+, K+-ATPase inhibitor omeprazole, 5-methoxy-2-(4-methoxy-3,
5-dimethyl-2-pyridinylmethylsulfinyl)-l#-benzimidazole, and analogues of omeprazole …
5-dimethyl-2-pyridinylmethylsulfinyl)-l#-benzimidazole, and analogues of omeprazole …
Tesaglitazar, a PPARα/γ agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats
…, E Lundholm, G Camejo, I Skånberg… - Toxicological …, 2007 - academic.oup.com
The development of the dual peroxisome proliferator–activated receptor (PPAR) α/γ agonist
tesaglitazar as an oral antidiabetic was recently discontinued. Here we present tumor data …
tesaglitazar as an oral antidiabetic was recently discontinued. Here we present tumor data …
Prediction of drug-induced liver injury in humans by using in vitro methods: the case of ximelagatran
K Kenne, I Skanberg, B Glinghammar, A Berson… - Toxicology in Vitro, 2008 - Elsevier
Objective: To investigate the possible mechanisms underlying the liver enzyme elevations
seen during clinical studies of long-term treatment (>35 days) with ximelagatran, and …
seen during clinical studies of long-term treatment (>35 days) with ximelagatran, and …
Omeprazole treatment does not affect the metabolism of caffeine
…, C Cederberg, S Eriksson, PO Lagerström, I Skånberg - Gastroenterology, 1991 - Elsevier
This study was performed to investigate the possible influence of repeated omeprazole dosing
on the metabolism of caffeine, which has been shown to reflect the activity of one specific …
on the metabolism of caffeine, which has been shown to reflect the activity of one specific …