Development of a xylazine constant rate infusion with or without butorphanol for standing sedation of horses

SK Ringer, KG Portier, I Fourel… - Veterinary anaesthesia …, 2012 - Elsevier
Objective To elaborate constant rate infusion (CRI) protocols for xylazine (X) and xylazine/butorphanol
(XB) which will result in constant sedation and steady xylazine plasma …

Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants

A Hodroge, C Longin-Sauvageon, I Fourel… - Archives of Biochemistry …, 2011 - Elsevier
Antivitamin K anticoagulants have been commonly used to control rodent pest all over the
world for more than 50years. These compounds target blood coagulation by inhibiting the …

[HTML][HTML] Population genetics, community of parasites, and resistance to rodenticides in an urban brown rat (Rattus norvegicus) population

…, E Gilot-Fromont, E Jourdain, A Hammed, I Fourel… - PloS one, 2017 - journals.plos.org
Brown rats are one of the most widespread urban species worldwide. Despite the nuisances
they induce and their potential role as a zoonotic reservoir, knowledge on urban rat …

[HTML][HTML] VKORC1 mutations detected in patients resistant to vitamin K antagonists are not all associated with a resistant VKOR activity

A Hodroge, B Matagrin, C Moreau, I Fourel… - Journal of Thrombosis …, 2012 - Elsevier
Background: The VKORC1 gene codes for the VKORC1 enzyme, which is responsible for
the reduction of vitamin K epoxide into vitamin K. VKORC1 enzyme is the target of vitamin K …

Management of rodent populations by anticoagulant rodenticides: toward third-generation anticoagulant rodenticides

M Damin-Pernik, B Espana, S Lefebvre, I Fourel… - Drug Metabolism and …, 2017 - ASPET
Second-generation anticoagulant rodenticides (SGARs) have been used since the 1980s for
pest management. They are highly efficient even in warfarin-resistant rodents. Nevertheless…

Core-shell LC–MS/MS method for quantification of second generation anticoagulant rodenticides diastereoisomers in rat liver in relationship with exposure of wild rats

I Fourel, M Damin-Pernik, E Benoit, V Lattard - Journal of Chromatography …, 2017 - Elsevier
Second generation anticoagulant rodenticides (SGARs), pesticides used worldwide to control
rodent populations, exist in two diastereoisomer chemical species because they own two …

Poisoning by anticoagulant rodenticides in humans and animals: causes and consequences

S Lefebvre, I Fourel, S Queffélec… - … -From Specific Toxic …, 2017 - books.google.com
Anticoagulant rodenticides (ARs) are a keystone of the management of rodent populations
in the world. The widespread use of these molecules raises questions on exposure and …

Determination of bromadiolone residues in fox faeces by LC/ESI-MS in relationship with toxicological data and clinical signs after repeated exposure

M Sage, I Fourel, M Cœurdassier, J Barrat… - Environmental …, 2010 - Elsevier
In many countries, the fox (Vulpes vulpes), predator of small mammals, is particularly
affected by anticoagulant rodenticides such as bromadiolone due to secondary poisoning. …

Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks

I Fourel, JM Cullen, J Saputelli, CE Aldrich… - Journal of …, 1994 - Am Soc Microbiol
Duck hepatitis B virus (DHBV) DNA synthesis in congenitally infected ducks is inhibited by 2'-deoxycarbocyclic
guanosine (2'-CDG). Three months of therapy reduces the number of …

Development of an ecofriendly anticoagulant rodenticide based on the stereochemistry of difenacoum

M Damin-Pernik, B Espana, S Besse, I Fourel… - Drug Metabolism and …, 2016 - ASPET
Difenacoum, an antivitamin K anticoagulant, has been widely used as rodenticide to manage
populations of rodents. Difenacoum belongs to the second generation of anticoagulant, and…