… Nutley, Isabel Walter and Huw TO Davies to be identified as authors of this work has
been asserted by them in accordance with the 1988 Copyright, Designs and Patents Act. …

The past decade has witnessed widespread interest in the development of policy and
practice that is better informed by evidence. Enthusiasm has, however, been tempered by …

Highlights • Degraders are an emerging modality which fall into the ‘beyond rule of 5’space.
• Poor permeability and solubility are critical features limiting oral absorption. • Optimisation …

‘Knowledge transfer’ has become established as shorthand for a wide variety of activities
linking the production of academic knowledge to the potential use of such knowledge in non-…

This paper draws out some of the key lessons to have emerged from the experience of
trying to ensure that public policy and professional practice are better informed by evidence. …

Early prediction of human clearance is often challenging, in particular for the growing
number of low-clearance compounds. Long-term in vitro models have been developed which …

This article draws on both a cross-sector literature review of mechanisms to promote
evidence-based practice and a specific review of ways of improving research use in social care. At …

The use of common formulation ingredients (categorized into six groups) for preclinical animal
studies has been assessed with respect to cytochrome P450 (CYP) inhibition, specifically …

English This article presents results from a systematic review of the effectiveness of different
mechanisms for promoting research use across the health, social care, criminal justice and …

The impact of the surface‐active formulation ingredients Cremophor EL, Tween 80 and
Solutol HS 15 on the intrinsic clearance (Cl int ) of midazolam (MDZ) was investigated in rat …