Purpose. The purpose of this study was to investigate the pH-dependent passive and active
transport of weakly basic drugs across the human intestinal epithelium. Methods. The …

The aim of this study was to investigate pH-dependent passive and active transport of acidic
drugs across Caco-2 cells. Therefore, the bidirectional pH-dependent transport of two acidic …

This study investigates the influence of the solid-state properties melting point (T m ), enthalpy
of melting (ΔH m ) and entropy of melting (ΔS m ) of a drug on its intrinsic solubility (S 0 ). …

The aim of the present study is to develop a method for predicting the site at which molecules
will be metabolized by CYP 2C9 (cytochrome P450 2C9) using a previously reported …

The cytochrome P450 (CYP) family is composed of a large group of monooxygenases that
mediate the metabolism of xenobiotics and endogenous compounds. CYP2C9, one of the …

The identification of metabolites is almost exclusively done with liquid chromatography/tandem
mass spectrometry (LC/MSMS) and despite the enormous progress in the development …

The sharing of legacy preclinical safety data among pharmaceutical companies and its
integration with other information sources offers unprecedented opportunities to improve the …

The synthesis of four new brassinosteroid analogs is reported. Two of them elicited high
activity as plant growth promoters. Also a new way to define the structural requirements, that …

The aim of this work is to present the anchor−GRIND methodology. Anchor-GRIND efficiently
combines a priori chemical and biological knowledge about the studied compounds with …

This study describes the generation of a three-dimensional quantitative structure activity
relationship (3D-QSAR) model for 29 structurally diverse, competitive CYP2C9 inhibitors …