Comparative study of the dose-dependence of OATP1B inhibition by rifampicin using probe drugs and endogenous substrates in healthy volunteers
I Takehara, T Yoshikado, K Ishigame, D Mori… - Pharmaceutical …, 2018 - Springer
Purpose To evaluate association of the dose-dependent effect of rifampicin, an OATP1B
inhibitor, on the plasma concentration–time profiles among OATP1B substrates drugs and …
inhibitor, on the plasma concentration–time profiles among OATP1B substrates drugs and …
Investigation of glycochenodeoxycholate sulfate and chenodeoxycholate glucuronide as surrogate endogenous probes for drug interaction studies of OATP1B1 and …
I Takehara, H Terashima, T Nakayama… - Pharmaceutical …, 2017 - Springer
Purpose To assess the use of glycochenodeoxycholate-3-sulfate (GCDCA-S) and
chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates in …
chenodeoxycholate 3- or 24-glucuronide (CDCA-3G or -24G) as surrogate endogenous substrates in …
Elucidation of N1-methyladenosine as a potential surrogate biomarker for drug interaction studies involving renal organic cation transporters
T Miyake, T Mizuno, I Takehara, T Mochizuki… - Drug Metabolism and …, 2019 - ASPET
Endogenous substrates are emerging biomarkers for drug transporters, which serve as
surrogate probes in drug-drug interaction (DDI) studies. In this study, the results of metabolome …
surrogate probes in drug-drug interaction (DDI) studies. In this study, the results of metabolome …
Effect of rifampicin on the plasma concentrations of bile acid-O-sulfates in monkeys and human liver-transplanted chimeric mice with or without bile flow diversion
I Takehara, N Watanabe, D Mori, O Ando… - Journal of …, 2019 - Elsevier
The present study examined the significance of enterohepatic circulation and the effect of
rifampicin [an inhibitor of organic anion–transporting polypeptide 1B (OATP1B)] on the plasma …
rifampicin [an inhibitor of organic anion–transporting polypeptide 1B (OATP1B)] on the plasma …
Development of a microfluidic system comprising dialysis and secretion components for a bioassay of renal clearance
Y Sakuta, I Takehara, KI Tsunoda, K Sato - Analytical Sciences, 2018 - Springer
We have developed a microfluidic bioassay system that mimics glomerular filtration and tubular
secretion in the kidney. The system consists of a peristaltic micropump (heart), a dialysis …
secretion in the kidney. The system consists of a peristaltic micropump (heart), a dialysis …
Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin–luciferase reaction in living cells by facilitating the intracellular …
T Furuya, I Takehara, A Shimura, H Kishimoto… - Biochemical and …, 2018 - Elsevier
Bioluminescence (BL) imaging based on d-luciferin (d-luc)–luciferase reaction allows
noninvasive and real-time monitoring of luciferase-expressing cells. Because BL intensity …
noninvasive and real-time monitoring of luciferase-expressing cells. Because BL intensity …
Evaluation of Collection and Processing Conditions for Gene Expression Analysis Using Human Myeloid Cells
H Miyashita, I Takehara, M Nishimura… - Biopreservation and …, 2024 - liebertpub.com
Background: The population of blast cells among peripheral blood mononuclear cells (PBMCs)
obtained from patients is a desirable specimen for analyzing gene expression in …
obtained from patients is a desirable specimen for analyzing gene expression in …
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers …
I Takehara, T Yoshikado, K Ishigame, D Mori… - Pharmaceutical …, 2019 - europepmc.org
There was a miscalculation of coproporphyrin I AUC 0-24h in the published article (Volume
35, Number 7). After the correction of AUC 0-24h, AUC ratio and R-square were re-calculated…
35, Number 7). After the correction of AUC 0-24h, AUC ratio and R-square were re-calculated…
[DOC][DOC] Design Histories and Design Studies in East Asia
Y Kikuchi, Y Lee, W Wong - Journal of Design History, 2011 - ualresearchonline.arts.ac.uk
… force for developing functional uniforms with traditional beauty in Japan in the 1950s and
created a context for Japanese designers who followed, such as Kenzō Takada, Issey Miyake …
created a context for Japanese designers who followed, such as Kenzō Takada, Issey Miyake …
Design histories and design studies in East Asia: Part 1
Y Kikuchi - Journal of Design History, 2011 - academic.oup.com
… force for developing functional uniforms with traditional beauty in Japan in the 1950s and
created a context for Japanese designers who followed, such as Kenzō Takada, Issey Miyake …
created a context for Japanese designers who followed, such as Kenzō Takada, Issey Miyake …