The compound (5Z)-5-[(5-bromo-1H-indol-3-yl)methylene]-3-(4-chlorobenzyl)-thiazolidine-2,4-dione
(LYSO-7) was synthesised in order to obtain a new type of anti-inflammatory drug, …

Thiazolidinediones (TZDs) are drugs used to treat type 2 diabetes mellitus; however, several
safety concerns remain regarding the available drugs in this class. Therefore, the search for …

Introduction Ischemia-Reperfusion (I/R) damage is one of the major challenges in cardiothoracic
surgeries and in a pathological manner, is identified by exacerbated damage signals …

Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor gamma (PPARγ)
agonists that improve insulin resistance but trigger side effects such as weight gain, edema, …

The aim of this study was to develop and validate a UV spectrophotometric method for
determination of LPSF/AC04 from inclusion complex and encapsulated into liposomes. The …

This article describes the synthesis of the new (2Z)-2-(4-methoxybenzylidene)-6-nitro-4H -benzo[1,4]thiazin-3-one,
(2Z)-2-(4-methoxybenzylidene)-4-methyl-6-nitro-4H-benzo[1,4]thiazin…

This work aimed to investigate plasma pharmacokinetics and tissue distribution of a new
acridine derivative 5-acridin-9-ylmethylene-3-(4-methyl-benzyl)-thiazolidine-2,4-dione (AC04) …

OBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic
lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel …

Introduction: Gout is considered to be an autoinflammatory disease and the presence of
monosodium urate (MSU) crystals stimulates activation of NPRL3 inflammasome and …

Eight new 5-arylidene-3-benzyl-thiazolidine-2,4-diones with halide groups on their benzyl
rings were synthesized and assayed in vivo to investigate their anti-inflammatory activities. …