Reported predictions of human in vivo hepatic clearance from in vitro data have used a variety
of values for the scaling factors human microsomal protein (MPPGL) and hepatocellularity …

A major focus in the study of metabolism and disposition of trichloroethylene (TCE) is to identify
metabolites that can be used reliably to assess flux through the various pathways of TCE …

… Evans MV, Chiu WA, Okino MS, Caldwell JC. 2009. Development of an updated PBPK
model for trichloroethylene and metabolites in mice, and its application to discern the role of …

Physiologically based pharmacokinetic (PBPK) models are sophisticated dosimetry models
that offer great flexibility in modeling exposure scenarios for which there are limited data. …

Scaling of metabolic clearance values from liver microsomal data or recombinantly expressed
cytochrome P450 enzymes to predict human hepatic clearance requires knowledge of the …

Human risk and exposure assessments require dosimetry information. Species-specific
tissue dose response will be driven by physiological and biochemical processes. While …

Reactions between chemicals used to disinfect drinking water and compounds present in
source waters produce chemical mixtures containing hundreds of disinfection byproducts (…

Physiologically-based pharmacokinetic (PBPK) modeling offers a scientifically-sound framework
for integrating mechanistic data on absorption, distribution, metabolism and elimination …

Liver disease is a major health issue characterized by several pathological changes, with
steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of …

Differences in biotransformation activities may alter the bioavailability or efficacy of drugs,
provide protection from certain xenobiotic and environmental agents, or increase toxicity of …