The-tocopherol analogue 3, 4-dihydro-6-hydroxy-Ar, iV, Ar, 2, 5, 7, 8-heptamethyl-2H-l-benzopyran-2-ethan£
iminium 4-methylbenzenesulfonate (la, MDL 73404) and its O-acetate lb (…

Tilorone hydrochloride, 2, 7-bis [2-(diethylamino) ethoxy]-9H-fluoren-9-one (11), was found
to prolong survival of mice infectedwith lethal challenges of encephalomyocarditis (EMC) …

5-(Tetradecyloxy)-2-furancarboxylic acid (91, RMI 14514) was found to lower blood lipids
and to inhibit fatty acid synthesis with minimal effects on liver weightand liver fat content. This …

A series of-tocopherol analogues was synthesized with potential therapeutic value for such
pathological conditions as stroke and trauma. A set ofcriteria such as the inhibition of in vitro …

A series of 4-aroyl-1, 3-dihydro-2R-imidazol-2-ones was synthesized and evaluated for
pharmacological activity in the anesthetized dog. Most members of this series produced dose-…

Analogues of-tocopherol and ascorbic acid with permanentlycationic substituents, ie,
phosphonium (8, 9), sulfonium (11), acylhydrazinium (13, 14), and ammonium (1, 16, 21), were …

Enoximone is a new cardiotonic agent, active by both intravenous and oral routes of
administration, that is being studied clinically for the treatment of patients with congestive heart …

Free radicals may cause part of the irreversible injury which occurs during myocardial infraction
and reperfusion. In the present study MDL 73404, an α-tocopherol analogue which is a …

Free radicals may cause some of the irreversible injury which occurs during myocardial
ischaemiaa nd reperfusion. In the present study the effects of a cardioselective, ree radical …

The new water-soluble ammonium-analog of α-tocopherol (vitamin E) (compound1: 3, 4-dihydro-6-hydroxy-N,
N, N-2, 5, 7, 8-heptamethyl-2H-1-benzopyran-2-ethanaminium 4-…