In the post-genomic era, several profiling tools have been developed to provide a more
comprehensive picture of tumour development and progression. The global analysis of …

Biofluid NMR spectroscopy is a powerful tool that provides a comprehensive metabolic profile
of the low molecular weight components in biofluids. These profiles reflect concentrations …

Metabolomics studies generate increasingly complex data tables, which are hard to summarize
and visualize without appropriate tools. The use of chemometrics tools, eg, principal …

Metabolite identification studies involve the detection and structural characterization of the
biotransformation products of drug candidates. These experiments are necessary throughout …

A fast and robust method for lipid profiling utilizing liquid chromatography coupled with mass
spectrometry has been demonstrated and validated for the analysis of human plasma. This …

The systemic biochemical effects of oral hydrazine administration (dosed at 75, 90, and 120
mg/kg) have been investigated in male Han Wistar rats using metabonomic analysis of 1 H …

Ultra-Performance LC (UPLC) utilizing sub-2-μm porous stationary phase particles operating
with high linear velocities at pressures >9000 psi was coupled with orthogonal acceleration …

The direct coupling of HPLC with NMR spectroscopy has been extended by splitting the HPLC
eluent after conventional UV detection and sending part to a NMR spectrometer and part …

A strategy for optimizing LC-MS metabolomics data processing is proposed. We applied this
strategy on the XCMS open source package written in R on both human and plant biology …

Interspecies variation between rats and mice has been studied for hydrazine toxicity using a
novel metabonomics approach. Hydrazine hydrochloride was administered to male Sprague…