User profiles for J R Bend
John R BendDistinguished University Professor, Emeritus of Pathology Western University Verified email at schulich.uwo.ca Cited by 10513 |
[8] Chemical depletion of glutathione in vivo
Publisher Summary The method for lowering tissue glutathione (GSH) levels involves the
administration of compounds that react enzymically with GSH to form conjugates. The …
administration of compounds that react enzymically with GSH to form conjugates. The …
Selective inhibitors of cytochromes P450
… of pulmonary vs hepatic P450 2B4 in rabbits (Mathews and Bend, 1993) and of P450 2Bx
in guinea pigs (Knickle and Bend, 1992a) following iv administration into the median ear vein …
in guinea pigs (Knickle and Bend, 1992a) following iv administration into the median ear vein …
Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish.
JJ Lech, JR Bend - Environmental health perspectives, 1980 - ehp.niehs.nih.gov
Many of the biotransformation reactions which have been described for xenobiotic substances
in mammals have been demonstrated in fish in both in vitro and in vivo experiments. …
in mammals have been demonstrated in fish in both in vitro and in vivo experiments. …
[HTML][HTML] Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells
Heme metabolism normally involves enzymatic conversion to biliverdin and subsequently to
bilirubin, catalyzed by heme oxygenase and biliverdin reductase, respectively. We …
bilirubin, catalyzed by heme oxygenase and biliverdin reductase, respectively. We …
Grapefruit‐felodipine interaction: effect of unprocessed fruit and probable active ingredients
…, C Munoz, DJ Freeman, JR Bend - Clinical …, 2000 - Wiley Online Library
Objectives To determine whether unprocessed grapefruit can cause a drug interaction, whether
the active ingredients are naturally occurring, and whether specific furanocoumarins or …
the active ingredients are naturally occurring, and whether specific furanocoumarins or …
Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice
DG Bailey, GK Dresser, JR Bend - Clinical Pharmacology & …, 2003 - Wiley Online Library
Objectives: Our objective was to assess the importance of bergamottin in drug interactions
through comparisons between grapefruit juice and lime juice and the potential for drug …
through comparisons between grapefruit juice and lime juice and the potential for drug …
Grapefruit juice—felodipine interaction: Effect of naringin and 6′, 7′‐dihydroxybergamottin in humans
…, C Munoz, DJ Freeman, JR Bend - Clinical …, 1998 - Wiley Online Library
Objective To test whether naringin or 6′,7′‐dihydroxybergamottin is a major active
substance in grape‐fruit juice‐felodipine interaction in humans. Methods Grapefruit juice was …
substance in grape‐fruit juice‐felodipine interaction in humans. Methods Grapefruit juice was …
Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review
Anticonvulsant hypersensitivity syndrome (AHS), also known by the other names drug rash (reaction)
with eosinophilia and systemic symptoms (DRESS) and drug-induced …
with eosinophilia and systemic symptoms (DRESS) and drug-induced …
[HTML][HTML] Health impact of pesticides on residents and horticultural workers in the Lake Naivasha Region, Kenya
The horticultural sector has undergone tremendous growth in Kenya and is now the second
largest foreign income earning sector in the country. Lake Naivasha is the hub of large scale …
largest foreign income earning sector in the country. Lake Naivasha is the hub of large scale …