Pharmacokinetics and pharmacodynamics of recombinant human interferon-β in healthy male volunteers

P Salmon, JY Le Cotonnec, A Galazka… - Journal of interferon & …, 1996 - liebertpub.com
The pharmacokinetics and pharmacodynamics of recombinant human interferon-beta (rHuIFN-β1a)
were assessed following administration to 12 healthy male volunteers. Each subject …

Clinical pharmacology of recombinant human follicle-stimulating hormone (FSH). I. Comparative pharmacokinetics with urinary human FSH

JY le Cotonnec, HC Porchet, V Beltrami, A Khan… - Fertility and sterility, 1994 - Elsevier
Objective To assess and compare the pharmacokinetics of recombinant human FSH with
those of a reference preparation of urinary human FSH. Design Urinary human FSH and …

Clinical pharmacology of recombinant human luteinizing hormone: Part I. Pharmacokinetics after intravenous administration to healthy female volunteers and …

JY le Cotonnec, HC Porchet, V Beltrami, A Munafo - Fertility and Sterility, 1998 - Elsevier
Objective: To assess the pharmacokinetics after IV administration of a recombinant human
LH and to compare them to those of a reference hMG preparation containing urinary human …

[HTML][HTML] Clinical pharmacology of recombinant human follicle-stimulating hormone. II. Single doses and steady state pharmacokinetics

JY le Cotonnec, HC Porchet, V Beltrami, A Khan… - Fertility and sterility, 1994 - Elsevier
Objective To assess the single-dose pharmacokinetics of a recombinant human FSH preparation
(Gonal-F; Laboratoires Serono, Aubonne, Switzerland), administered by IV, IM, and SC …

Pharmacokinetic and pharmacodynamic interactions between recombinant human luteinizing hormone and recombinant human follicle-stimulating hormone

JY le Cotonnec, E Loumaye, HC Porchet, V Beltrami… - Fertility and sterility, 1998 - Elsevier
Objective: To assess the pharmacokinetics of a recombinant human LH preparation and its
pharmacokinetic and pharmacodynamic interactions with recombinant human follicle-…

Endocrinology: Comparative pharmacokinetics of two urinary human follicle stimulating hormone preparations in healthy female and male volunteers

JY le Cotonnec, HC Porchet, V Beltrami… - Human …, 1993 - academic.oup.com
These studies were designed to compare the pharmacokinetic characteristics of a very
highly purified urinary human follicle stimulating hormone (FSH-HP) preparation (sp. act. ∼9000 …

Clinical pharmacology of recombinant human luteinizing hormone: Part II. Bioavailability of recombinant human luteinizing hormone assessed with an immunoassay …

JY le Cotonnec, HC Porchet, V Beltrami, A Munafo - Fertility and Sterility, 1998 - Elsevier
Objective: To assess the single-dose pharmacokinetics of a recombinant human LH preparation
administered by the IV, IM, and SC route. Design: Prospective, randomized cross-over …

Biosimilar rhG-CSFs: how similar are they?

P Gravel, A Naik, JY Le Cotonnec - Targeted oncology, 2012 - Springer
Biosimilars are more affordable copycat versions of originator biological products in much
the same way as generics are copies of small molecule pharmaceuticals. However, while …

Pharmacokinetics of recombinant human luteinizing hormone after intravenous, intramuscular, and subcutaneous administration in monkeys and comparison with …

HC Porchet, JY Le Cotonnec… - The Journal of …, 1995 - academic.oup.com
To assess the pharmacokinetics of recombinant human LH (rhLH) in monkeys, we measured
serum LH levels after single iv injection and after single and repeated doses by the im or sc …

Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide

…, A Munafo, JY Le Cotonnec… - American Journal …, 1996 - journals.physiology.org
A pharmacodynamic analysis of the input-response relationship between the gonadotropin-releasing
hormone antagonist antide and luteinizing hormone (LH) and testosterone …