INTRODUCTION: Primary human hepatocytes are considered as a highly predictive in vitro
model for preclinical drug metabolism studies. Due to the limited availability of human liver …

A bioreactor construction for hepatocytes and liver sinusoidal endothelial cells is described.
The reactor is based on capillaries for hepatocyte immobilization. Four discrete capillary …

Within the scope of developing an in vitro culture model for pharmacological research on
human liver functions, a three-dimensional multicompartment hollow fiber bioreactor proven to …

Methods. Primary liver cells were isolated from 54 discarded organs (donor age 56.7±13.2
years). Between 2.8× 10 10 and 6.4× 10 10 parenchymal cells (PC) were cocultured with …

Based on a hollow fiber perfusion technology with internal oxygenation, a miniaturized bioreactor
with a volume of 0.5 mL for in vitro studies was recently developed. Here, the suitability …

To further differentiate adipose-derived stem cells (ASCs) into mature adipocytes and create
three-dimensional (3D) adipose tissue in vitro, we applied multicompartment hollow fiber-…

Although hepatic cell transplantation (CT) holds the promise of bridging patients with end-stage
chronic liver failure to whole liver transplantation, suitable cell populations are under …

Human mesenchymal stem cells can be isolated from various organs and are in studies on
therapeutic cell transplantation. Positive clinical outcomes of transplantations have been …

Background: Acute liver failure (ALF) remains a disease with high mortality. Bioartificial liver
support systems, which combine living cells of the liver in an extracorporeal circuit, have …

Results Using skin-cell spray transplantation grafting, the “expansion” ratio of skin donor site
to treatment surface area was approximately 1: 20, indicating that we could cover a larger …