[HTML][HTML] Guidelines for the welfare and use of animals in cancer research

…, A Balmain, G Bruder, DJ Chaplin, JA Double… - British journal of …, 2010 - nature.com
Animal experiments remain essential to understand the fundamental mechanisms underpinning
malignancy and to discover improved methods to prevent, diagnose and treat cancer. …

Quantitative Angiogenesis Assays in vivo – A Review

J Hasan, SD Shnyder, M Bibby, JA Double, R Bicknel… - Angiogenesis, 2004 - Springer
The development of agents that target tumour vasculature is ultimately dependent on the
availability of appropriate preclinical screening assays. Several quantitative angiogenesis …

The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function

…, F Dai, CM Schultes, AP Reszka, MJ Moore, JA Double… - Cancer research, 2005 - AACR
… Tumor doubling time of test and control groups was defined as the period required to double
the initial tumor volume (100%) to 200%. Growth curves were analyzed in terms of maximal …

A critical appraisal of the predictive value of in vitro chemosensitivity assays

RM Phillips, MC Bibby, JA Double - JNCI: Journal of the …, 1990 - academic.oup.com
The ultimate value of a screening program based on the response of cell lines in vitro will
depend on the demonstration of a strong correlation between in vitro and in vivo responses to …

Inhibition of telomerase activity by cisplatin in human testicular cancer cells

AM Burger, JA Double, DR Newell - European Journal of Cancer, 1997 - Elsevier
Telomerase, a ribonucleoprotein, elongates and/or maintains telomeres by adding TTAGGG
tandem repeat sequences using the RNA component of the enzyme as a template. Enzyme …

Distribution, metabolism and tumoricidal activity of doxorubicin administered in sorbitan monostearate (Span 60) niosomes in the mouse

IF Uchegbu, JA Double, JA Turton, AT Florence - Pharmaceutical research, 1995 - Springer
… Modest tumour targeting was achieved by the delivery of doxorubicin in sorbitan monostearate
niosomes, increasing the tumour to heart AUC'2“ ratio from 0.27 to 0.36 and a doubling of …

[HTML][HTML] Antitumour 2-(4-aminophenyl) benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo

…, PB Farmer, MC Bibby, PA Cooper, JA Double… - British journal of …, 2003 - nature.com
2-(4-Aminophenyl) benzothiazoles represent a potent and highly selective class of antitumour
agent. In vitro, sensitive carcinoma cells deplete 2-(4-aminophenyl) benzothiazoles from …

Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl) benzothiazoles

TD Bradshaw, MC Bibby, JA Double, I Fichtner… - Molecular Cancer …, 2002 - AACR
Novel 2-(4-aminophenyl)benzothiazoles (eg, compounds 1 and 2) possess highly selective,
potent antitumor properties in vitro and in vivo. Elucidation of the mechanism of action of this …

Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development

…, PA Batman, J Griffith, C Bradley, JA Double… - Molecular cancer …, 2003 - AACR
The cytochrome P450 family of enzymes is involved in the Phase I metabolism of a wide
variety of compounds. Although generally involved with detoxification, overexpression of one …

Synthesis, mechanism of action, and biological evaluation of mitosenes

…, HH Fiebig, BR Winterhalter, JA Double… - Journal of medicinal …, 1989 - ACS Publications
Mitosenes of both the pyrrolo-and pyrido [l, 2-a] indole type have been prepared viamodification
of these heterotricyclic compounds. Several mitosenes have been studied for their …