The growth of siRNA-based therapeutics: Updated clinical studies

…, R Bahal, TP Rasmussen, JE Manautou… - Biochemical …, 2021 - Elsevier
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity

CI Ghanem, MJ Pérez, JE Manautou… - Pharmacological …, 2016 - Elsevier
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to
be safe when administered within its therapeutic range, but in cases of acute intoxication, …

[PDF][PDF] Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional …

…, Y Tanaka, GL Scheffer, JY Chan, JE Manautou… - …, 2007 - Wiley Online Library
Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent
transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, …

Molecular mechanisms underlying chemical liver injury

X Gu, JE Manautou - Expert reviews in molecular medicine, 2012 - cambridge.org
… XG, postdoctoral fellow in José Manautou’s laboratory, was supported by the National …
Manautou (2012) Molecular mechanisms underlying chemical liver injury. Expert Rev. Mol. …

Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease

LM Aleksunes, JE Manautou - Toxicologic pathology, 2007 - journals.sagepub.com
Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper
family and is activated in response to electrophiles and reactive oxygen species. Nrf2 …

Nrf2: a potential target for new therapeutics in liver disease

AM Bataille, JE Manautou - Clinical Pharmacology & …, 2012 - Wiley Online Library
Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription
factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been …

Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity

…, CE Rockwell, J Thomale, JE Manautou… - … of Pharmacology and …, 2010 - ASPET
The use of the chemotherapeutic drug cisplatin is limited in part by nephrotoxicity. Cisplatin
causes renal DNA adducts and oxidative stress in rodents. The transcription factor Nrf2 (…

Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice

…, JY Lee, SI Koo, M O'Connor, JE Manautou… - The Journal of nutritional …, 2011 - Elsevier
Excess hepatic lipid accumulation and oxidative stress contribute to nonalcoholic fatty liver
disease (NAFLD). Thus, we hypothesized that the hypolipidemic and antioxidant activities of …

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

…, NJ Cherrington, CD Klaassen, JE Manautou - Toxicology and applied …, 2008 - Elsevier
The transcription factor NFE2-related factor 2 (Nrf2) mediates detoxification and antioxidant
gene transcription following electrophile exposure and oxidative stress. Mice deficient in Nrf2 …

Absorption, distribution, metabolism, and excretion of US Food and Drug Administration–Approved antisense oligonucleotide drugs

…, S Nair, R Bahal, TP Rasmussen, JE Manautou… - Drug Metabolism and …, 2022 - ASPET
Absorption, distribution, metabolism, and excretion (ADME) are the key biologic processes
for determination of a drug’s pharmacokinetic parameters, which have direct impacts on …